The Adipose Tissue Microenvironment Regulates Depot-Specific Adipogenesis in Obesity.
The Adipose Tissue Microenvironment Regulates Depot-Specific Adipogenesis in Obesity.
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DOI：
10.1016/j.cmet.2016.05.012
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发表时间：
2016-07-12
期刊：
影响因子：
29
通讯作者：
Rodeheffer MS
中科院分区：
文献类型：
--
作者：
Jeffery E;Wing A;Holtrup B;Sebo Z;Kaplan JL;Saavedra-Peña R;Church CD;Colman L;Berry R;Rodeheffer MS
脂肪组织的性二态分布影响肥胖相关病理的发展。雄性动物内脏白色脂肪组织（VWAT）的积累对代谢健康有害，而雌性动物皮下脂肪组织（SWAT）的积累可能具有保护作用。在这里，我们表明，脂肪细胞增生直接有助于性别之间的脂肪分布差异。在雄性小鼠中，高脂饮食（HFD）诱导脂肪形成，特别是在VWAT，而在雌性小鼠中，HFD诱导脂肪形成在VWAT和SWAT在性别依赖性的方式。我们还表明，激活的脂肪细胞前体（AP），驱动脂肪细胞增生的肥胖症，是由脂肪贮库微环境，而不是由细胞内在机制。这些发现表明，AP是可塑性细胞，其响应于影响其分化潜能的局部和系统信号，而与储库来源无关。因此，特定的AP微环境生态位协调脂肪组织的生长和分布。Jeffrey等人研究了雄性和雌性小鼠对高脂肪饮食的反应中脂肪库扩张的差异。皮下白色脂肪组织（SWAT）扩张仅发生在女性中。此外，白色脂肪细胞前体的库特异性活化和分化由微环境而不是细胞内在差异决定。
The sexually dimorphic distribution of adipose tissue influences the development of obesity-associated pathologies. The accumulation of visceral white adipose tissue (VWAT) that occurs in males is detrimental to metabolic health, while accumulation of subcutaneous adipose tissue (SWAT) seen in females may be protective. Here, we show that adipocyte hyperplasia contributes directly to the differential fat distribution between the sexes. In male mice, high-fat diet (HFD) induces adipogenesis specifically in VWAT, while in females HFD induces adipogenesis in both VWAT and SWAT in a sex hormone-dependent manner. We also show that the activation of adipocyte precursors (APs), which drives adipocyte hyperplasia in obesity, is regulated by the adipose depot microenvironment and not by cell-intrinsic mechanisms. These findings indicate that APs are plastic cells, which respond to both local and systemic signals that influence their differentiation potential independent of depot origin. Therefore, depot-specific AP microenvironment niches coordinate adipose tissue growth and distribution. Jeffrey et al look at differences in fat depot expansion in male and female mice in response to a high fat diet. Subcutaneous white adipose tissue (SWAT) expansion only occurs in females. Furthermore depot-specific activation and differentiation of white adipocyte precursors is determined by the microenvironment rather than cell-intrinsic differences.