Is hypertension in African-descent populations contributed to by an imbalance in the activities of the ACE2/Ang-(1-7)/Mas and the ACE/Ang II/AT1 axes?
Is hypertension in African-descent populations contributed to by an imbalance in the activities of the ACE2/Ang-(1-7)/Mas and the ACE/Ang II/AT1 axes?
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DOI：
10.1177/1470320320908186
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发表时间：
2020-01-01
影响因子：
2.9
通讯作者：
Nunez-Smith, Marcella
中科院分区：
文献类型：
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作者：
Cohall, Damian;Ojeh, Nkemcho;Nunez-Smith, Marcella
低血浆肾素活性高血压是普遍存在于非洲-加勒比人。在高血压前期、2型糖尿病和慢性肾病患者中，有报道称肾素血管紧张素醛固酮系统的反血管紧张素转换酶2 /血管紧张素-(1-7)/Mas受体轴的血管紧张素转换酶2活性降低。本研究探讨了肾素-血管紧张素-醛固酮系统的升压臂（血管紧张素转换酶/血管紧张素II/AT1受体）和降压轴（血管紧张素转换酶2/血管紧张素-(1-7)/Mas受体）之间的调节机制失衡是否使非洲人后裔易患高血压。方法：将从巴巴多斯的公共部门综合诊所招募30名血压正常者和30名新近诊断的高血压患者，年龄在18-55岁，来自加勒比非洲，他们对降压治疗缺乏经验。将收集人口统计和人体测量数据、临床血压读数、24小时尿液收集和静脉血样本。生物样品将分析肾素血管紧张素醛固酮系统肽标记物使用放射免疫分析法。结论：我们描述了肾素血管紧张素醛固酮系统机制的设计、方法和基本原理，这些机制可能有助于非洲裔人的高血压易感性。我们的研究结果将描述非洲-加勒比地区高血压患者肾素血管紧张素醛固酮系统反轴的任何不平衡，并有可能确定使用肾素血管紧张素醛固酮系统和矿化皮质激素阻滞剂来控制病情的新方法。
Introduction: Low plasma renin activity hypertension is prevalent in Afro-Caribbean persons. Reduced angiotensin converting enzyme 2 activity from the counter angiotensin converting enzyme 2 /angiotensin-(1-7)/Mas receptor axis of the renin angiotensin aldosterone system has been reported in people with pre-hypertension, type 2 diabetes mellitus and chronic renal disease. This study investigates whether an imbalance in the regulatory mechanisms between the pressor arm of the renin angiotensin aldosterone system (angiotensin converting enzyme/angiotensin II/AT1 receptor) and the depressor axis (angiotensin converting enzyme 2/angiotensin-(1-7)/Mas receptor) predisposes persons of African descent to hypertension.Methods: In total, 30 normotensives and 30 recently diagnosed hypertensives aged 18-55 of Afro-Caribbean origin who are naive to antihypertensive treatment will be recruited from public sector polyclinics in Barbados. Demographic and anthropometric data, clinical blood pressure readings, 24-hour urine collections and venous blood samples will be collected. Biological samples will be analysed for renin angiotensin aldosterone system peptide markers using radioimmunoassay.Conclusion: We describe the design, methods and rationale for the characterization of renin angiotensin aldosterone system mechanisms that may contribute to hypertension predisposition in persons of African descent. Our findings will characterize any imbalance in the counter axes of the renin angiotensin aldosterone system in hypertensive Afro-Caribbeans with a potential view of identifying novel approaches with the use of renin angiotensin aldosterone system and mineralocorticoid blockers to manage the condition.