MICROGLIAL AGGREGATION IN THE DENTATE GYRUS - A MARKER OF MILD HYPOXIC-ISCHEMIC BRAIN INSULT IN HUMAN INFANTS
MICROGLIAL AGGREGATION IN THE DENTATE GYRUS - A MARKER OF MILD HYPOXIC-ISCHEMIC BRAIN INSULT IN HUMAN INFANTS
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DOI：
10.1111/j.1365-2990.1994.tb01173.x
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发表时间：
1994-04-01
影响因子：
5
通讯作者：
BECKER, LE
中科院分区：
文献类型：
--
作者：
DELBIGIO, MR;BECKER, LE
在实验动物中有许多报道表明，缺氧缺血性脑损伤后齿状回和海马中的小胶质细胞被激活。对178例儿童尸检取出的大脑海马进行了回顾性研究，并对齿状回多形层中的小胶质细胞数量进行了评估。在8 - 9个月龄之前，因围产期窒息、先天性心脏缺陷或慢性肺功能障碍而有确诊的缺氧或低血压发作的患者，常常有密集的小胶质细胞浸润。在大多数符合婴儿猝死综合征情况死亡的儿童中也观察到了类似的小胶质细胞浸润。9个月以下因其他急性原因（例如创伤或败血症）突然死亡或在重症监护病房存活不到4天的儿童，其小胶质细胞明显较少。9个月龄之后，无论死亡原因如何，都从未见到密集的小胶质细胞浸润。我们得出结论，人类婴儿齿状回多形层中大量小胶质细胞的存在是慢性疾病或轻度缺氧缺血性脑损伤的标志，这种损伤需要数天时间发展。
There are many reports in experimental animals indicating that microglia are activated in the dentate gyrus and hippocampus following hypoxic-ischaemic brain injury. The hippocampi of brains removed at autopsy from 178 children were studied retrospectively and the quantity of microglia in the polymorphous layer of the dentate gyrus was assessed. Up to the age of 8-9 months, patients with proven hypoxic or hypotensive episodes due to perinatal asphyxia, congenital heart defects, or chronic pulmonary dysfunction often had a dense infiltrate of microglial cells. A comparable microglial infiltrate was seen in most children dying under circumstances consistent with sudden infant death syndrome. Children under 9 months of age dying of other acute causes, for example trauma or sepsis either suddenly or with survival of less than 4 days in the intensive care unit, had significantly fewer microglia. After the age of 9 months a dense microglial infiltrate was never seen regardless of the cause of death. We conclude that the presence of abundant microglia in the polymorphous layer of the dentate gyrus of human infants is a marker of chronic illness or mild hypoxic-ischaemic brain injury which takes several days to develop.