Differences in resting cerebellar and prefrontal cortical blood flow in spinal cord injury-related neuropathic pain: A brief report.
Differences in resting cerebellar and prefrontal cortical blood flow in spinal cord injury-related neuropathic pain: A brief report.
复制标题
脊髓损伤相关神经性疼痛中静息小脑和前额皮质血流的差异：简短报告。
DOI：
10.1080/10790268.2020.1786321
复制
发表时间：
2021
期刊：
影响因子：
--
通讯作者：
Richards,JScott
中科院分区：
文献类型：
--
作者：
Richardson,ElizabethJ;Deutsch,Georg;Deshpande,HrishikeshD;Richards,JScott
背景：人们对脊髓损伤（SCI）相关神经病理性疼痛患者静息神经活动的差异了解甚少。这项试点研究的目的是确定与SCI相关的神经性疼痛的人相比，健康，无痛健全controls.Methods：5人截瘫和10个健全的参与者静息脑血流量的差异包括在这项研究中。静息血流量，作为测量的连续动脉自旋标记（ASL）方法的功能磁共振成像，通过统计参数mapping.Results：SCI相关的神经病理性疼痛的人有显着较低的静息血流量在小脑（脚I/II），头端腹内侧延髓和左岛皮质。相比之下，更大的静息血流量发生在内侧眶额皮质与SCI相关的神经病理性pain. Conclusions相比：静息血流量的差异，观察与SCI相关的疼痛，特别是在该地区可能涉及的情感动机和认知评价方面的疼痛。除了使用功能磁共振成像的功能连接研究之外，还需要更大的ASL研究来阐明这种复杂且通常难以治疗的疼痛形式的独特神经模式。
Context:Little is understood about differences in resting neural activity among those with spinal cord injury (SCI)-related neuropathic pain. The purpose of this pilot study was to determine resting cerebral blood flow differences in persons with SCI-related neuropathic pain compared to healthy, pain-free able-bodied controls.Methods:Five persons with paraplegia and ten able-bodied participants were included in this study. Resting blood flow, as measured by a continuous arterial spin labeling (ASL) method of fMRI, was analyzed via statistical parametric mapping.Results:Persons with SCI-related neuropathic pain had significantly lower resting blood flow in the cerebellum (Crus I/II), rostral ventromedial medulla and left insular cortex. In contrast, greater resting blood flow occurred in the medial orbitofrontal cortex among those with SCI-related neuropathic pain compared to controls.Conclusion:Differences in resting blood flow were observed among those with SCI-related pain, particularly in regions that may be involved in affective-motivational and cognitive-evaluative aspects of pain. Larger ASL studies in addition to functional connectivity studies using fMRI are needed to clarify unique neural patterns in this complex and often intractable form of pain.