Autophagy in cancer.
Autophagy in cancer.
复制标题
DOI：
10.12703/p7-18
复制
发表时间：
2015
期刊：
影响因子：
--
通讯作者：
Zhong Q
中科院分区：
文献类型：
--
作者：
Zhi X;Zhong Q
自噬是细胞内蛋白质和细胞器被双膜自噬体吞噬并在溶酶体中降解的分解代谢降解过程。自噬已成为肿瘤发展和癌症治疗的关键途径，尽管其确切功能仍然是一个谜。目前的共识是自噬在癌症中具有双重作用。一方面，自噬通过防止受损细胞器和聚集蛋白的积累而作为肿瘤抑制机制发挥作用。另一方面，自噬是已建立的肿瘤的关键细胞存活机制;因此自噬抑制抑制肿瘤进展。本文就自噬在肿瘤发生和肿瘤治疗中的作用作一综述。
Autophagy is a catabolic degradation process in which cellular proteins and organelles are engulfed by double-membrane autophagosomes and degraded in lysosomes. Autophagy has emerged as a critical pathway in tumor development and cancer therapy, although its precise function remains a conundrum. The current consensus is that autophagy has a dual role in cancer. On the one hand, autophagy functions as a tumor suppressor mechanism by preventing the accumulation of damaged organelles and aggregated proteins. On the other hand, autophagy is a key cell survival mechanism for established tumors; therefore autophagy inhibition suppresses tumor progression. Here, we summarize recent progress on the role of autophagy in tumorigenesis and cancer therapy.