Disequilibrium in distribution of resistance mutations among Mycobacterium tuberculosis Beijing and non-beijing strains isolated from patients in Germany
Disequilibrium in distribution of resistance mutations among Mycobacterium tuberculosis Beijing and non-beijing strains isolated from patients in Germany
复制标题
DOI：
10.1128/aac.49.3.1229-1231.2005
复制
发表时间：
2005-03-01
影响因子：
4.9
通讯作者：
Niemann, S
中科院分区：
文献类型：
--
作者：
Hillemann, D;Kubica, T;Niemann, S
对2001年在德国分离的103株多重耐药结核分枝杆菌菌株的基因型分析显示，rpoB基因的密码子531（75.7%）和katG基因的密码子315（88.4%）突变最常见。北京基因型菌株（占所有分离株的60.2%）显示出与非北京菌株不同的耐药突变分布。
Genotypic analysis of 103 multidrug-resistant Mycobacterium tuberculosis strains isolated in Germany in 2001 revealed that mutations in codon 531 (75.7%) of the rpoB gene and codon 315 (88.4%) of the katG gene are most frequent. Beijing genotype strains (60.2% of all isolates) displayed a different distribution of resistance mutations than non-Beijing strains.