EFFECTS OF INFUSED SODIUM-ACETATE, SODIUM LACTATE, AND SODIUM BETA-HYDROXYBUTYRATE ON ENERGY-EXPENDITURE AND SUBSTRATE OXIDATION RATES IN LEAN HUMANS
EFFECTS OF INFUSED SODIUM-ACETATE, SODIUM LACTATE, AND SODIUM BETA-HYDROXYBUTYRATE ON ENERGY-EXPENDITURE AND SUBSTRATE OXIDATION RATES IN LEAN HUMANS
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DOI：
10.1093/ajcn/58.5.608
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发表时间：
1993-11-01
影响因子：
7.1
通讯作者：
TAPPY, L
中科院分区：
文献类型：
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作者：
CHIOLERO, R;MAVROCORDATOS, P;TAPPY, L
在瘦人中输注醋酸钠导致呼吸交换率降低。这在呼吸衰竭患者中可能是有利的。然而，观察到呼吸功的这种潜在减少被显著的产热所抵消。醋酸钠、乳酸钠和β-羟基丁酸钠以20 mumol速率输注的代谢效应。kg-1 . min-1持续3 h，在6名健康志愿者中进行监测。呼吸交换率从基线时的0.85 +/- 0.02分别降至醋酸盐、乳酸盐或β-羟基丁酸盐后的0.75 +/-0.02、0.75 +/- 0.02和0.80 +/- 0.02（各P < 0.05）。醋酸盐产生的热效应（占输注能量的22.7%）大于乳酸盐（16.3%）或β-羟基丁酸盐（13.6%）。因此，有机酸的钠盐可能通过降低呼吸交换率而潜在地降低呼吸需求。然而，这种效应被这些基底的热效应部分抵消。这些阴离子在较大输注期间的最大剂量和安全性仍有待确定。
Infusion of sodium acetate in lean humans results in a decrease in respiratory exchange ratio. which may be advantageous in patients with respiratory failure. However, this potential decrease in respiratory work was observed to be offset by significant thermogenesis. The metabolic effects of sodium acetate, sodium lactate, and sodium beta-hydroxybutyrate, infused at a rate of 20 mumol . kg-1 . min-1 for 3 h, was monitored in six healthy human volunteers. Respiratory exchange ratio decreased from 0.85 +/- 0.02 at baseline to 0.75 +/- 0.02, 0.75 +/- 0.02, and 0.80 +/- 0.02, after acetate, lactate, or beta-hydroxybutyrate, respectively (P < 0.05 for each). Acetate produced a larger thermic effect (22.7% of energy infused) than did lactate (16.3%) or beta-hydroxybutyrate (13.6%). Thus, sodium salts of organic acids may potentially decrease the respiratory requirements by decreasing the respiratory exchange ratio. However, this effect is partially offset by the thermic effect of these substrates. The maximal doses and safety of these anions during larger infusion periods remain to be determined.