Magnesia-doped HA/beta-TCP ceramics and evaluation of their biocompatibility.
Magnesia-doped HA/beta-TCP ceramics and evaluation of their biocompatibility.
复制标题
氧化镁掺杂HA/β-TCP陶瓷及其生物相容性评价。
作者：
H. Ryu;K. Hong;Jung‐Kun Lee;D. Kim;Jae Hyup Lee;B. Chang;Dong;Choon;S. Chung
研究了氧化镁掺杂的羟基磷灰石/磷酸三钙双相陶瓷的烧结行为、力学性能和生物相容性。由于β-向α-磷酸三钙的相变，纯HA/TCP陶瓷的烧结性较差。掺入氧化镁的HA/TCP陶瓷密度高，在1300℃以下不发生任何β-磷酸三钙的相变，掺入氧化镁的β-磷酸三钙陶瓷的热稳定性较好。但当氧化镁的加入量超过某一临界值时，抑制了HA/TCP陶瓷的晶粒长大，降低了其烧结性。最佳的氧化镁掺杂量为1wt%，其相对密度为99%，力学性能优于HA或β-TCP陶瓷。体外实验和体内实验表明，1wt%的氧化镁掺杂的羟基磷灰石/磷酸三钙陶瓷具有良好的生物相容性，无细胞毒性。植入兔肌肉后，β-磷酸三钙从表面溶解，表面覆盖一层生物磷灰石。这些结果表明，在不改变原始复合材料的生物安全性和生物相容性的情况下，添加MgO显著提高了HA/β-TCP陶瓷的烧结性能和力学性能。
The sintering behavior, mechanical properties and biocompatibility of magnesia (MgO)-doped HA/TCP biphasic ceramics were studied. Pure HA/TCP ceramics showed poor sinterability due to the phase transformation of beta- to alpha-TCP. MgO-doped HA/TCP ceramics showed high density without any phase transformation of beta-TCP up to 1300 degrees C, for MgO dopants incorporated into the beta-TCP preferably and increased thermal stability of beta-TCP. However, the addition of MgO higher than a critical content, suppressed grain growth of HA/TCP ceramics and lowered sinterability. The optimum amount of MgO doping was 1 wt%, which lead 99% relative density and higher mechanical properties than HA or beta-TCP ceramics. From in vitro test and in vivo test, 1 wt% MgO-doped HA/TCP ceramics showed a good biocompatibility without cytotoxicity. After implantation under the muscle of rabbits, beta-TCP phase was dissolved from the surface and a biological apatite covered the surface. These results proved that MgO addition increased drastically the sintering and mechanical properties of HA/beta-TCP ceramics without altering the biological safety and biocompatibility of the original composite.