Zebrafish Leopard gene as a component of the putative reaction-diffusion system
Zebrafish Leopard gene as a component of the putative reaction-diffusion system
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DOI：
10.1016/s0925-4773(99)00211-7
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发表时间：
1999-12-01
影响因子：
2.6
通讯作者：
Kondo, S
中科院分区：
文献类型：
--
作者：
Asai, R;Taguchi, E;Kondo, S
在理论基础上，已经提出了反应扩散（RD）机制是动物色素模式形成的基础，但到目前为止，还没有分子证据证明这一假设的机制。斑马鱼基因的突变，豹纹，把斑纹从条纹变成了斑点。有趣的是，每个等位基因都有一个特征模式，其斑点大小、密度和连通性各不相同。单个基因的突变可以产生如此多样的模式，这可以用RD模型来理解。所有豹子突变体的模式变化都可以在模拟中通过改变一个参数值来产生，这个参数值对应于一个假定的RD系统中的反应动力学。代入该参数的中间值使模式与杂合子鱼相似。这些结果表明，豹子基因产物是推测的RD机制的一个组成部分。(C) 1999爱思唯尔科学爱尔兰有限公司版权所有
It has been suggested, on a theoretical basis, that a reaction-diffusion (RD) mechanism underlies pigment pattern formation in animals, but as yet, there is no molecular evidence for the putative mechanism. Mutations in the zebrafish gene, leopard, change the pattern from stripes to spots. Interestingly each allele gives a characteristic pattern, which varies in spot size, density and connectivity. That mutations in a single gene can generate such a variety of patterns can be understood using a RD model. All the pattern variations of leopard mutants can be generated in a simulation by changing a parameter value that corresponds to the reaction kinetics in a putative RD system. Substituting an intermediate value of the parameter makes the patterns similar to the heterozygous fish. These results suggest that the leopard gene product is a component of the putative RD mechanism. (C) 1999 Elsevier Science Ireland Ltd, All rights reserved.