A motor cortex circuit for motor planning and movement
A motor cortex circuit for motor planning and movement
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DOI：
10.1038/nature14178
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发表时间：
2015-03-05
期刊：
影响因子：
64.8
通讯作者：
Svoboda, Karel
中科院分区：
文献类型：
--
作者：
Li, Nuo;Chen, Tsai-Wen;Svoboda, Karel
运动皮层的活动在特定的动作发生前几秒钟就能预测它们，但这种准备活动与即将发生的动作之间的关系尚不清楚。我们剖析了在结构化的运动皮层回路中准备活动到运动的转换。小鼠皮层的前外侧区域（灵长类动物中的前额叶皮层的可能同源物）包含相同比例的混合神经元，预测同侧或对侧运动，但在运动规划过程中，该皮层区域的单侧失活会破坏对侧运动。使用细胞类型特异性电生理学，细胞成像和光遗传学扰动，我们表明，第5层神经元投射在皮层内具有无偏侧化。活动与对侧人口的偏见，特别是在第5层神经元投射到brairststern，只有在运动规划后期。这些结果揭示了分层组织的皮层电路内的运动命令的分布准备活动的转换。
Activity in motor cortex predicts specific movements seconds before they occur, but how this preparatory activity relates to upcoming movements is obscure. We dissected the conversion of preparatory activity to movement within a structured motor cortex circuit. An anterior lateral region of the mouse cortex (a possible homologue of prernotor cortex in primates) contains equal proportions of intermingled neurons predicting ipsi- or contralateral movements, yet unilateral inactivation of this cortical region during movement planning disrupts contralateral movements. Using cell-type-specific electrophysiology, cellular imaging and optogenetic perturbation, we show that layer 5 neurons projecting within the cortex have unbiased laterality. Activity with a contralateral population bias arises specifically in layer 5 neurons projecting to the brairtstern, and only late during movement planning. These results reveal the transformation of distributed preparatory activity into movement commands within hierarchically organized cortical circuits.