Risks of selected congenital malformations among offspring of mixed race-ethnicity.
Risks of selected congenital malformations among offspring of mixed race-ethnicity.
复制标题
混合种族后代中特定先天畸形的风险。
DOI：
10.1002/bdra.20054
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发表时间：
2004
期刊：
影响因子：
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通讯作者：
Shaw,GaryM
中科院分区：
文献类型：
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作者：
Yang,Juan;Carmichael,SuzanL;Kaidarova,Zhanna;Shaw,GaryM
背景：关于混合种族后代中特定的先天畸形的发生情况，我们知之甚少。方法根据一项基于人群的登记数据，我们探索了不同种族的父母在后代中发生特定畸形表型的情况。数据来自加州出生缺陷监测计划，这是一个基于人群的主动监测系统，通过多来源确定收集患有先天性畸形的婴儿和胎儿的信息。1989-2000年期间发生了大约260万次活产和死产。父母的种族信息(非西班牙裔白人、西班牙裔、黑人和亚洲人)是从出生证明和胎儿死亡文件中获得的。研究的畸形表型有脊柱裂、无脑、唇裂、腭裂、法洛四联症、大动脉转位、尿道下裂、小肠闭锁、轴前性多指畸形、小拇指畸形和肥厚性幽门狭窄。与双亲都是白人的出生相比，在几个种族-种族混合的出生群体中，观察到无脑儿、多指和小耳畸形的风险(风险比≥为1.7%)适度增加，而尿道下裂和肥厚性幽门狭窄的风险(风险比≤为0.6%)降低。对于无脑儿、多指畸形和小耳畸形，但不包括其他表型，风险是不同的，这取决于是否考虑母系和父系种族。在大多数畸形表型中，观察到的非白人父母和白人父母之间的出生风险与父母都是非白人的出生风险相似。结论基于混合种族-民族分组，一些畸形表型的风险似乎有所不同。出生缺陷研究(A部分)，2004年。©2004 Wiley-Liss Inc.
BACKGROUNDLittle is known about the occurrence of specific congenital malformations among offspring of mixed race‐ethnicity.METHODSUsing data from a population‐based registry, we explored the occurrence of selected malformation phenotypes in offspring to parents who were of different race‐ethnicity. Data were derived from the California Birth Defects Monitoring Program, a population‐based active surveillance system for collecting information on infants and fetuses with congenital malformations using multiple source ascertainment. Approximately 2.6 million live births and stillbirths occurred during 1989–2000. Information on parental race‐ethnicity (non‐Hispanic white, Hispanic, black, and Asian) was obtained from birth certificates and fetal death files. Malformation phenotypes studied were spina bifida, anencephaly, cleft lip, cleft palate, tetralogy of Fallot, d‐transposition of great arteries, hypospadias, small intestinal atresia, preaxial polydactyly, microtia, and hypertrophic pyloric stenosis.RESULTSA total of 11.2% of births were to parents of mixed race‐ethnicity. Compared to births of parents who were both white, moderately increased risks (risk ratio ≥ 1.7) of anencephaly, polydactyly, and microtia, and decreased risks (risk ratio ≤ 0.6) of hypospadias and hypertrophic pyloric stenosis were observed among births of several mixed race‐ethnicity groups. For anencephaly, polydactyly, and microtia, but not other phenotypes, the risks were different depending on whether maternal versus paternal race‐ethnicity was considered. Risks observed between births of a nonwhite parent and a white parent and births of parents who were both nonwhite were similar for most malformation phenotypes.CONCLUSIONSSome malformation phenotypes appear to vary in their risk based on mixed racial‐ethnic groupings. Birth Defects Research (Part A), 2004. © 2004 Wiley‐Liss, Inc.