Anti-glucose-6-phosphate isomerase, anti-cyclic citrullinated peptide antibodies and HLA-DRB1 genotypes in Japanese patients with early rheumatoid arthritis.
Anti-glucose-6-phosphate isomerase, anti-cyclic citrullinated peptide antibodies and HLA-DRB1 genotypes in Japanese patients with early rheumatoid arthritis.
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发表时间：
2008-09
影响因子：
3.7
通讯作者：
T. Furuya;I. Matsumoto;N. Tsuchiya;M. Hakoda;N. Ichikawa;T. Yago;K. Higami;Y. Nanke;T. Sumida;N. Kamatani;S. Kotake
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作者：
T. Furuya;I. Matsumoto;N. Tsuchiya;M. Hakoda;N. Ichikawa;T. Yago;K. Higami;Y. Nanke;T. Sumida;N. Kamatani;S. Kotake
目的：探讨日本早期类风湿关节炎（RA）患者抗葡萄糖-6-磷酸异构酶（GPI）抗体（Abs）、抗环瓜氨酸肽（CCP）抗体和HLA-DRB 1基因型的相关性。方法对108例发病1年内就诊的早期RA患者（男23例，女85例）进行抗GPI抗体、抗CCP抗体检测，并进行HLA-DRB 1基因分型。同时检测63例正常对照组和265例健康对照组的抗GPI和抗CCP抗体水平及HLA-DRB 1基因型。结果108例早期RA患者和63例对照组中，抗GPI Ab阳性分别为20例（18.5%）和3例（4.8%）。在20例抗GPI抗体阳性的患者中，17例（85%）抗CCP抗体阳性。HLA-DRB 1 *0405和共享表位（SE）携带者频率不仅在抗GPI Ab阳性患者中显著增加，（p=0.00057，比值比[OR] 4.6，95% CI 1.8-11.8; p=0.0011，OR 5.0，95% CI 1.7-14.0），而且在抗GPI Ab阴性患者中也是如此（p=0.0017，OR 2.2，95% CI 1.3-3.7; p=0.00011，OR 2.6，95% CI 1.6-4.3）。此外，与对照组相比，抗GPI Ab阳性患者中HLA-DRB 1 *1201的携带者频率显著增加（p=0.0056，OR 4.3，95%CI 1.4-13.2）。结论大多数抗GPI Ab阳性的RA患者构成了HLA-DRB 1 * SE相关的抗CCP Ab阳性的RA患者的子集。
OBJECTIVE Our goal was to evaluate the associations of antibodies (Abs) to glucose-6-phosphate isomerase (GPI) with Abs to cyclic citrullinated peptide (CCP) and HLA-DRB1 genotypes in Japanese patients with early rheumatoid arthritis (RA). METHODS One hundred and eight patients with early RA (85 female, 23 male) who visited our clinic within 1 year of symptom onset were examined for anti-GPI and anti-CCP Ab levels, and HLA-DRB1 genotype. Anti-GPI and anti-CCP Ab levels, and HLA-DRB1 genotypes were also determined in 63 controls and 265 healthy controls, respectively. RESULTS Of the 108 patients with early RA and the 63 controls, 20 (18.5%) and 3 (4.8%) were anti-GPI Ab-positive, respectively. Of the 20 patients with anti-GPI Abs, 17 (85%) were positive for anti-CCP Abs. HLA-DRB1*0405 and shared epitope (SE) carrier frequencies were significantly increased not only in anti-GPI Ab-positive patients (p=0.00057, odds ratio [OR] 4.6, 95% CI 1.8-11.8; p=0.0011, OR 5.0, 95% CI 1.7-14.0), but also in anti-GPI Ab-negative patients (p=0.0017, OR 2.2, 95% CI 1.3-3.7; p=0.00011, OR 2.6, 95% CI 1.6-4.3), when compared with controls. In addition, the carrier frequency of HLA-DRB1*1201 was significantly increased in anti-GPI Ab-positive patients compared with controls (p=0.0056, OR 4.3, 95% CI 1.4-13.2). CONCLUSIONS The majority of anti-GPI Ab-positive RA patients constitute a subset of HLA-DRB1* SE-associated, anti-CCP Ab-positive RA patients.