Platelet-Mimic uPA Delivery Nanovectors Based on Au Rods for Thrombus Targeting and Treatment
Platelet-Mimic uPA Delivery Nanovectors Based on Au Rods for Thrombus Targeting and Treatment
复制标题
基于金棒的模拟血小板 uPA 递送纳米载体用于血栓靶向和治疗
DOI：
10.1021/acsbiomaterials.8b00979
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发表时间：
2018
影响因子：
--
通讯作者：
Hongbo Xin
中科院分区：
文献类型：
--
作者：
Ting Yang;Xingwei Ding;Lina Dong;Can Hong;Jing Ye;Yunfei Xiao;Xiaolei Wang;Hongbo Xin
全身性溶栓药物由于其解毒剂的快速中和作用，始终取得不理想的治疗效果。寻找一种将溶栓药物靶向递送至血栓的方法具有重要意义。这里制造了一种生物相容性、血栓靶向且低成本的模拟血小板纳米载体，以实现在血栓部位持续释放尿激酶纤溶酶原激活剂（uPA）。所制备的系统在体外表现出30小时的持续模型药物释放行为和近红外激光热照射下的爆发释放行为。我们证明所制造的纳米载体可以到达并聚集在肺血栓处，然后在小鼠肺栓塞模型中持续释放uPA。因此，根据结果，配制的纳米载体在临床靶向溶栓治疗中具有广阔的应用前景。
Systemic thrombolytic drug administration has always gained an unideal therapeutic effect due to the rapid neutralization by its antidotes. It is significant to seek an approach for targeted thrombolytic drug delivery to the thrombus. Here a biocompatible, thrombus-targeted, and low-cost platelet-mimic nanovector was fabricated to accomplish a sustained urokinase plasminogen activator (uPA) release at the thrombus site. The prepared system presented a sustained model drug release behavior for 30 h and burst release behavior under near-infrared laser irradiation with hyperthermia in vitro. We demonstrate that the fabricated nanovectors can arrive and aggregate at the pulmonary thrombus, followed by a sustained uPA release in the murine pulmonary embolism model. Therefore, according to the results, the formulated nanovector presented a hopeful application for targeted thrombolytic therapy clinically.