Environmental exposure to arsenic and chromium in children is associated with kidney injury molecule-1
Environmental exposure to arsenic and chromium in children is associated with kidney injury molecule-1
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DOI：
10.1016/j.envres.2016.06.032
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发表时间：
2016-10-01
影响因子：
8.3
通讯作者：
Vaidya, V. S.
中科院分区：
文献类型：
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作者：
Cardenas-Gonzalez, M.;Osorio-Yanez, C.;Vaidya, V. S.
自然或人类来源的环境危害非常普遍，特别是在墨西哥中北部地区。儿童因其独特的接触途径和特殊的脆弱性而成为易感人群。在这项研究中，我们评估了居住在墨西哥圣路易斯波托西 (SLP) 的儿童接触环境肾毒物与肾损伤生物标志物的关联。对 SLP 雷耶斯镇 83 名儿童（5-12 岁）居民进行了一项横断面研究。通过尿液、血液和饮用水样本评估砷、镉、铬、氟化物和铅的暴露情况。几乎所有自来水和井水样本的砷（81.5%）和氟化物（100%）含量均高于世界卫生组织建议的允许水平。平均尿液砷（45.6 ppb）和铬（61.7 ppb）高于生物暴露指数（职业环境中的参考值）。使用多变量调整模型，我们发现肾损伤分子 1 (KIM-1) 与铬暴露三分位数之间存在剂量依赖性关联 [(T1：参考，12：467 pg/mL；T3：615 pg/mL) (p 趋势 = 0.001)]。铬上三分位数还与较高的尿液 miR-200c（500 拷贝/μL）和 miR-423（189 拷贝/μL）相关。砷上三分位数还与较高的尿 KIM-1 (372 pg/mL) 相关。其他肾损伤/功能性生物标志物，如血清肌酐、肾小球滤过率、白蛋白尿、中性粒细胞明胶酶相关脂质运载蛋白和 miR-21，未显示与砷、铬或任何其他评估的毒物有任何关联。我们得出的结论是，KIM-1 可能作为一种敏感的生物标志物来筛查儿童因环境有毒物质引起的肾脏损伤。 (C) 2016 Elsevier Inc. 保留所有权利。
Environmental hazards from natural or anthropological sources are widespread, especially in the north central region of Mexico. Children represent a susceptible population due to their unique routes of exposure and special vulnerabilities. In this study we evaluated the association of exposure to environmental kidney toxicants with kidney injury biomarkers in children living in San Luis Potosi (SLP), Mexico. A cross-sectional study was conducted with 83 children (5-12 years of age) residents of Villa de Reyes, SLP. Exposure to arsenic, cadmium, chromium, fluoride and lead was assessed in urine, blood and drinking water samples. Almost all tap and well water samples had levels of arsenic (81.5%) and fluoride (100%) above the permissible levels recommended by the World Health Organization. Mean urine arsenic (45.6 ppb) and chromium (61.7 ppb) were higher than the biological exposure index, a reference value in occupational settings. Using multivariate adjusted models, we found a dose-dependent association between kidney injury molecule-1 (KIM-1) across chromium exposure tertiles [(T1: reference, 12: 467 pg/mL; T3: 615 pg/mL) (p-trend=0.001)]. Chromium upper tertile was also associated with higher urinary miR-200c (500 copies/mu l) and miR-423 (189 copies/mu L). Arsenic upper tertile was also associated with higher urinary KIM-1 (372 pg/mL). Other kidney injury/functional biomarkers such as serum creatinine, glomerular filtration rate, albuminuria, neutrophil gelatinase-associated lipocalin and miR-21 did not show any association with arsenic, chromium or any of the other toxicants evaluated. We conclude that KIM-1 might serve as a sensitive biomarker to screen children for kidney damage induced by environmental toxic agents. (C) 2016 Elsevier Inc. All rights reserved.