Toward a vaccine for AIDS: the emergence of immunobiology-based vaccine development.
Toward a vaccine for AIDS: the emergence of immunobiology-based vaccine development.
复制标题
走向艾滋病疫苗：基于免疫生物学的疫苗开发的出现。
DOI：
10.1146/annurev.iy.12.040194.004423
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发表时间：
1994
影响因子：
29.7
通讯作者：
Berzofsky,JA
中科院分区：
文献类型：
--
作者：
Cease,KB;Berzofsky,JA
Over a decade has passed since the identification of the human immunodeficiency virus (HIV) as the causative agent of AIDS. During this time, HIV has been extensively characterized, and a variety of vaccine constructs and strategies have been explored. For the most part, these have been driven by successes of the past with other pathogens, or by novel approaches enabled by technologies of the present. With the maturing of our insights into the immunopathology of HIV and basic immunological mechanisms, we are presented with unprecedented opportunities to rationally develop vaccine approaches strategically designed to counter the immunopathology of HIV. As opposed to absolute prevention of infection, the primary goal of these strategies may be to limit infection and to assure a response to infection that prevents disease and transmission. Thus, such vaccines may find utility in both preventive and therapeutic roles. In this paper, we present the background and current state of immunobiology-driven vaccine development for AIDS.
