Relative and Absolute Stereochemistry of Quinadoline B, an Inhibitor of Lipid Droplet Synthesis in Macrophages
Relative and Absolute Stereochemistry of Quinadoline B, an Inhibitor of Lipid Droplet Synthesis in Macrophages
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DOI：
10.1021/ol802089p
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发表时间：
2008-11-20
期刊：
影响因子：
5.2
通讯作者：
Tomoda, Hiroshi
中科院分区：
文献类型：
--
作者：
Koyama, Nobuhiro;Inoue, Yusuke;Tomoda, Hiroshi
从曲霉FKI-1746的发酵液中分离到两个新的真菌代谢产物，命名为喹哪啉A（1）和喹哪啉8（2）。通过X射线晶体学和氨基酸分析，使用手性柱确定2的完整的相对和绝对立体化学。喹哪啉类药物适度抑制小鼠巨噬细胞中的脂滴合成。
New fungal metabolites, designated quinadolines A (1) and 8 (2), were isolated from culture broth of Aspergillus sp. FKI-1746, and their structures were elucidated by NMR spectroscopy. The complete relative and absolute stereochemistry of 2 was determined by X-ray crystallography and amino acid analysis using a chiral column. Quinadolines moderately inhibited lipid droplet synthesis in mouse macrophages.