Corneal densitometry and its correlation with age, pachymetry, corneal curvature, and refraction
Corneal densitometry and its correlation with age, pachymetry, corneal curvature, and refraction
复制标题
DOI：
10.1007/s10792-016-0397-y
复制
发表时间：
2017-12-01
影响因子：
1.6
通讯作者：
Argueso, Francisco
中科院分区：
文献类型：
--
作者：
Garzon, Nuria;Poyales, Francisco;Argueso, Francisco
为了确定年龄、性别、屈光不正、角膜厚度和角膜屈光度与年龄、性别、屈光度的关系的标准角膜密度测量值，使用Oculus Pentacam系统测量了338名健康受试者(男性185人，女性153人)，并进行了详尽的眼部检查。角膜密度以标准化灰度单位(GSU)表示，平均角膜面积密度为16.46+/-1.85GSU。皮尔逊相关系数r=0.542(p<；0.001)。男性和女性之间的总面积差异有统计学意义(p=0.006)，读数分别为16.22+/-1.54GSU和16.60+/-1.83GSU。当角膜被分成不同深度的层时，各层与年龄之间存在显著的相关性：前层r=0.447(p<；0.001)，中央层r=0.563(p<；0.001)，后层r=0.520(p<；0.001)。然而，当从角膜中心开始将角膜分成同心环时，在6-10 mm的环中，密度测量仅与年龄密切相关(p<；0.001)。在角膜的任何区域，平均角膜屈光度和等值球镜与角膜密度计均无相关性(p>；0.05)。这是用最新的Oculus Pentacam软件测量的与角膜屈光度、角膜厚度和等值球镜相关的标准角膜密度值的第一个报告。角膜密度随年龄增长而增加，但角膜屈光度和屈光参数不影响人角膜的光散射。
To determine normative corneal densitometry values in relation to age, sex, refractive error, corneal thickness, and keratometry, measured using the Oculus Pentacam system.Three hundred and thirty-eight healthy subjects (185 men; 153 women) with no corneal disease underwent an exhaustive ocular examination. Corneal densitometry was expressed in standardized grayscale units (GSU).The mean corneal densitometry over the total area was 16.46 +/- 1.85 GSU. The Pearson correlation coefficient for total densitometry was r = 0.542 (p < 0.001). Statistically significant differences were found between men and women for the total area (p = 0.006), with readings of 16.22 +/- 1.54 GSU and 16.60 +/- 1.83 GSU, respectively. When the cornea was divided into layers of different depths, a significant correlation was found for all layers and age: r = 0.447 (p < 0.001), r = 0.563 (p < 0.001), and r = 0.520 (p < 0.001) for the anterior, central, and posterior layers, respectively. However, when the cornea was divided into concentric annuli starting from the center of the cornea, densitometry was strongly correlated only with age in the 6-10-mm annulus (p < 0.001). Neither mean keratometry nor spherical equivalent was correlated with corneal densitometry in any zone of the cornea (p > 0.05).This is the first report of normative corneal densitometry values in relation to keratometry, corneal thickness, and spherical equivalent measured with the latest Oculus Pentacam software. Corneal densitometry increases with age, but corneal keratometry and refractive parameters do not affect light scattering in the human cornea.