Molecular architecture of the complete COG tethering complex.
Molecular architecture of the complete COG tethering complex.
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DOI：
10.1038/nsmb.3263
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发表时间：
2016-08
影响因子：
16.8
通讯作者：
Hughson FM
中科院分区：
文献类型：
--
作者：
Ha JY;Chou HT;Ungar D;Yip CK;Walz T;Hughson FM
保守的寡聚体高尔基体(COG)复合体协调囊泡运输到高尔基体和高尔基体内。在这里，我们使用负染色电子显微镜来阐明来自酿酒酵母的异八聚体COG复合体的结构。完整的COG具有复杂的形状，有四条(或可能五条)灵活的腿，与外囊复合体截然不同，看起来非常适合囊泡捕获和融合。
The conserved oligomeric Golgi (COG) complex orchestrates vesicular trafficking to and within the Golgi apparatus. Here, we use negative-stain electron microscopy to elucidate the architecture of the hetero-octameric COG complex from Saccharomyces cerevisiae. Intact COG has an intricate shape, with four (or possibly five) flexible legs, that differs strikingly from the exocyst complex and appears well-suited for vesicle capture and fusion.