Well-differentiated papillary mesothelioma
Well-differentiated papillary mesothelioma
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DOI：
10.1097/00000478-200110000-00012
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发表时间：
2001-10-01
影响因子：
5.6
通讯作者：
Roggli, VL
中科院分区：
文献类型：
--
作者：
Butnor, KJ;Sporn, TA;Roggli, VL
分化良好的乳头状间皮瘤是上皮间皮瘤的一个不寻常的变种，被认为是低恶性潜力。以前报告的大多数病例发生在没有石棉暴露史的年轻女性的腹膜中。作者报告了14例分化良好的乳头状间皮瘤，其中7例起源于胸膜，6例起源于腹膜，1例起源于图尼卡迷走神经。11例患者为男性，3例为女性，平均年龄为58岁（范围32-82岁）。其中6名患者有可量化的石棉暴露史。在完成随访的9例病例中，6例为临床惰性疾病，1例在辅助化疗后显示消退，1例进行了积极的治疗，1例死于其他原因。这些研究结果表明，分化良好的乳头状间皮瘤是间皮瘤的一种罕见的变种，具有可变的临床预后，在某些情况下，在病因学上与石棉暴露有关。
Well-differentiated papillary mesothelioma is an unusual variant of epithelial mesothelioma considered to be of low malignant potential. The majority of previously reported cases developed in the peritoneum of young women without a history of asbestos exposure. The authors report 14 cases of well-differentiated papillary mesothelioma, seven of which originated in the pleura, six in the peritoneum, and one in the tunica vaginalis. Eleven of the patients were male and three were female, with an average age at presentation of 58 years (range 32-82 years). Six of the patients had a quantifiable history of asbestos exposure. Of the nine cases with complete follow-up, six had clinically indolent disease, one showed resolution after adjuvant chemotherapy, one pursued an aggressive course, and one died of other causes. These findings indicate that well-differentiated papillary mesothelioma is a rare variant of mesothelioma with a variable clinical prognosis that is etiologically related to asbestos exposure in some cases.