Neighborhood Disadvantage and Cumulative Biological Risk Among a Socioeconomically Diverse Sample of African American Adults: An Examination in the Jackson Heart Study
Neighborhood Disadvantage and Cumulative Biological Risk Among a Socioeconomically Diverse Sample of African American Adults: An Examination in the Jackson Heart Study
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DOI：
10.1007/s40615-015-0157-0
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发表时间：
2016-09-01
影响因子：
3.9
通讯作者：
Earls, Felton
中科院分区：
文献类型：
--
作者：
Barber, Sharrelle;Hickson, DeMarc A.;Earls, Felton
社区的特点是不利的影响慢性病的多种危险因素，被认为是美国种族和民族健康不平等的潜在驱动因素。本研究的目的是探讨邻里劣势和累积生物风险（CBR）之间的关系，并在多大程度上，该协会不同的个人收入和教育之间的一个大的，社会经济上不同的样本的非洲裔adults.Methods数据从基线检查的杰克逊心脏研究（2000-2004年）被用于分析。样本由年龄在21-85岁的非裔美国人组成，具有关于CBR生物标志物和行为协变量的完整地理编码数据（n=4410）。邻里劣势是用2000年美国人口普查的社会经济指标综合得分来衡量的。使用代表心血管、代谢、炎症和神经内分泌系统的八种生物标志物来创建CBR评分。结果在协变量调整后，居住在弱势社区与较高的CBR相关（B=0.18，标准误（SE）0.07，p
Objectives Neighborhoods characterized by disadvantage influence multiple risk factors for chronic disease and are considered potential drivers of racial and ethnic health inequities in the USA. The objective of the present study was to examine the relationship between neighborhood disadvantage and cumulative biological risk (CBR) and the extent to which the association differs by individual income and education among a large, socioeconomically diverse sample of African American adults.Methods Data from the baseline examination of the Jackson Heart Study (2000-2004) were used for the analyses. The sample consisted of African American adults ages 21-85 with complete, geocoded data on CBR biomarkers and behavioral covariates (n=4410). Neighborhood disadvantage was measured using a composite score of socioeconomic indicators from the 2000 US Census. Eight biomarkers representing cardiovascular, metabolic, inflammatory, and neuroendocrine systems were used to create a CBR score. We fit two-level linear regression models with random intercepts and included cross-level interaction terms between neighborhood disadvantage and individual socioeconomic status (SES).Results Living in a disadvantaged neighborhood was associated with greater CBR after covariate adjustment (B=0.18, standard error (SE) 0.07, p