The obesity of patients with Laron Syndrome is not associated with excessive nutritional intake
The obesity of patients with Laron Syndrome is not associated with excessive nutritional intake
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DOI：
10.1016/j.orcp.2008.11.001
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发表时间：
2009-03-01
影响因子：
4.3
通讯作者：
Vaisman, Nachum
中科院分区：
文献类型：
--
作者：
Ginsberg, Shira;Laron, Zvi;Vaisman, Nachum
目的：研究可能影响Laron综合征患者超重的代谢参数。设计：测量每个患者的身体成分、每日热量摄入量和静息能量消耗(REE)。根据7天的食物记录计算卡路里摄入量，用间接量热法测定REE，用双能X射线吸收法(DEXA)测定身体成分。结果：与正常人群相比，Laron综合征患者存在异常高的体脂(BF)质量(占体重的54+/-10%)和相对较低的瘦体质量(LBM)。能量摄入量各不相同，但大多数患者的能量摄入量并不显着高于测量的REE。根据我们对健康成年人的标准，经LBM校正的REE高于预期。食物中碳水化合物、蛋白质和脂肪的平均分布分别为47%、17%和36%。结论：Laron综合征患者的严重肥胖不是由于吞噬过多或代谢不足所致。(C)2008年亚洲大洋洲肥胖症研究协会。爱思唯尔有限公司出版。保留所有权利。
Objective: To study the metabolic parameters which may affect the excessive weight of treated and untreated patients with Laron Syndrome.Design: Body composition, daily caloric intake and resting energy expenditure (REE), when possible, were measured for each patient. Caloric intake was calculated based on 7-day food records, REE was measured by indirect calorimetry and body composition was determined by dual energy X-ray absorptiometry (DEXA).Subjects: Nine untreated adult subjects with Laron Syndrome (6 female subjects, 3 mate subjects) aged 28-53 years and 4 girls with Laron Syndrome treated by insulin-like growth factor-1 (IGF-1) 120-150 mu g/kg/d were included in the study.Results: Patients with Laron Syndrome have an abnormally high body fat (BF) mass (54 +/- 10% of body weight) and a relatively low lean body mass (LBM) compared to a healthy normal population. Energy intake varied but in most of the patients was not significantly higher than the measured REE. The REE corrected for LBM was higher than expected, based on our norms for healthy adults. The mean distribution of energy sources in the food was 47% carbohydrates, 17% protein and 36% fat.Conclusion: The severe obesity of patients with Laron Syndrome is not due to hyperphagia or hypometabolism. (C) 2008 Asian Oceanian Association for the Study of Obesity. Published by Elsevier Ltd. All rights reserved.