Higher ultra-processed food intake was positively associated with odds of NAFLD in both US adolescents and adults: A national survey.
Higher ultra-processed food intake was positively associated with odds of NAFLD in both US adolescents and adults: A national survey.
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DOI：
10.1097/hc9.0000000000000240
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发表时间：
2023-09-01
影响因子：
5.1
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中科院分区：
文献类型：
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超加工食品（UPF）对NAFLD的影响尚不清楚。成人NAFLD的相关证据有限，目前还没有研究评估UPF对青少年NAFLD的影响。我们使用了国家健康和营养检查调查（2017-2018）的数据，其中包括806名青少年和2734名成年人。UPF的摄入量是使用两次24小时饮食回忆的饮食数据估计的。通过瞬时弹性成像确定NAFLD。Logistic回归用于估计UPF和NAFLD之间关联的多变量OR和95%CI，并进行调查体重调整。青少年的平均UPF摄入量为812 g/d，成人为823 g/d。共有12.4%的青少年和35.6%的成年人患有NAFLD。在青少年（OR五分位数5 vs.四分位数1 = 2.34，95% CI，1.01，5.41; p趋势= 0.15）和成人（OR五分位数5 vs.五分位数1 = 1.72，95% CI，1.01，2.93; p趋势= 0.002）中，较高的UPF摄入量与较高的NAFLD几率相关。在成年人中，UPF摄入量和NAFLD之间的相关性分别约68%和71%由体重指数和腰围介导（所有p值< 0.001）。青少年的结果相似，但没有统计学意义。在成人中，较高的UPF摄入量与较低的血清白蛋白水平和较高的C反应蛋白水平相关。在青少年和成人中，较高的UPF摄入量与较高的NAFLD几率有关，主要是因为身体脂肪增加。如果得到证实，减少UPF摄入量可能有助于预防青少年和成人的NAFLD。
The effect of ultra-processed foods (UPF) on NAFLD remains unclear. Related evidence for adult NAFLD is limited and no study has yet evaluated UPF’s impact on NAFLD in adolescence. We used data from the National Health and Nutrition Examination Survey (2017-2018) with 806 adolescents and 2734 adults. UPF intake was estimated using dietary data from two 24-hour dietary recalls. NAFLD was defined by transient elastography. Logistic regression was used to estimate the multivariable OR and 95% CI for associations between UPF and NAFLD with survey weight adjustments. The mean UPF intake was 812 g/d in adolescents and 823 g/d in adults. A total of 12.4% of the adolescents and 35.6% of the adults had NAFLD. Higher UPF intake was associated with higher odds of NAFLD in both adolescents (OR Quintile 5 vs. Quartile 1 = 2.34, 95% CI, 1.01, 5.41; p trend = 0.15) and adults (OR Quintile 5 vs. Quintile 1 = 1.72, 95% CI, 1.01, 2.93; p trend = 0.002). In adults, ~68% and 71% of the association between UPF intake and NAFLD was mediated by body mass index and waist circumference (all p-values < 0.001), respectively. The results were similar for adolescents but not statistically significant. A higher UPF intake was associated with lower levels of serum albumin and higher levels of C-reactive protein in adults. Higher UPF intake was linked to higher NAFLD odds in both adolescents and adults, mainly because of elevated body fatness. If confirmed, reducing UPF intake may help prevent NAFLD in both adolescents and adults.