Low Level of Regulatory T Cells and Maintenance of Balance Between Regulatory T Cells and TH17 Cells in HIV-1-Infected Elite Controllers
Low Level of Regulatory T Cells and Maintenance of Balance Between Regulatory T Cells and TH17 Cells in HIV-1-Infected Elite Controllers
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DOI：
10.1097/qai.0b013e318215a991
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发表时间：
2011-06-01
影响因子：
3.6
通讯作者：
Karlsson, Ingrid
中科院分区：
文献类型：
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作者：
Brandt, Lea;Benfield, Thomas;Karlsson, Ingrid
背景：HIV-1感染者的一个亚群，精英控制者，具有自发的病毒控制能力，为研究可能参与HIV-1感染控制的病毒学和免疫学因素提供了一个难得的机会。方法：对3组不同HIV-1感染者的外周血单个核细胞中Tregs和TH17细胞的频率进行评估，并与疾病进展的标志相关联：未接受治疗的病毒感染者、成功接受高效抗逆转录病毒治疗的个体和精英控制者。结果：我们证明精英控制者的Treg水平低于HIV-1感染的病毒携带者，但无论是自然控制还是治疗诱导的HIV-1控制者的低Treg水平在HIV-1控制者之间没有差异。我们还发现，T细胞的激活和增殖都与Tregs的水平有关。最后，在精英控制者和未感染对照组中，TH17/Treg比率相似，而在病毒携带者和经治疗的HIV-1感染者中，TH17/Treg比率低于未感染对照组。结论：我们表明，自发控制HIV-1的一个特征是调节性T细胞和TH17细胞之间保持平衡。
Background: A subgroup of HIV-1-infected individuals, elite controllers, have spontaneous viral control and offer an exceptional opportunity to study virological and immunolocigal factors of possible involvement in control of HIV-1 infection.Methods: The frequencies of Tregs and TH17 cells was evaluated and correlated to markers of disease progression in peripheral blood mononuclear cells from 3 different groups of individuals infected with HIV-1: treatment-naive viremic individuals, individuals on successful highly active antiretroviral therapy, and elite controllers. In addition, a group of HIV-1-negative individuals were included.Results: We demonstrate that elite controllers have lower levels of Tregs compared with HIV-1-infected viremic individuals, but that the low Treg level does not differ between individuals with HIV-1 control, whether natural or therapy induced. We also show that T-cell activation and proliferation both correlate to the level of Tregs. Finally, the TH17/Treg ratio was similar in Elite Controllers and uninfected controls, whereas in viremic and treated HIV-1-infected individuals, the TH17/Treg ratio was lower compared with uninfected controls.Conclusions: We show that one feature of spontaneous HIV-1 control is a maintained balance between regulatory T cells and TH17 cells.