Rab1 in cell signaling, cancer and other diseases.
Rab1 in cell signaling, cancer and other diseases.
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DOI：
10.1038/onc.2016.81
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发表时间：
2016-11-03
期刊：
影响因子：
8
通讯作者：
Zheng XF
中科院分区：
文献类型：
--
作者：
Yang XZ;Li XX;Zhang YJ;Rodriguez-Rodriguez L;Xiang MQ;Wang HY;Zheng XF
内质网和高尔基膜系统在细胞信号传导以及蛋白质和脂质生物合成/运输的调节中发挥着重要作用，以响应氨基酸和胆固醇水平等环境因素。 Rab1 是 Rab 小 GTP 酶家族的创始成员，已知该家族介导内质网和高尔基体之间的动态膜运输。越来越多的证据表明，Rab1 蛋白具有超出其经典囊泡运输功能的重要功能，包括营养感应和信号传导、细胞迁移和细胞表面受体的呈递。此外，RAB1表达失调与多种人类疾病有关，例如癌症、心肌病和帕金森病。进一步研究 Rab1 的这些新的生理和病理功能应该为更好地理解疾病过程提供新的机会，并可能导致更有效的治疗干预。
The ER and Golgi membrane system plays major roles in cell signaling and regulation of the biosynthesis/transport of proteins and lipids in response to environmental cues such as amino acid and cholesterol levels. Rab1 is the founding member of the Rab small GTPase family, which is known to mediate dynamic membrane trafficking between ER and Golgi. Growing evidence indicate that Rab1 proteins have important functions beyond their classical vesicular transport functions, including nutrient sensing and signaling, cell migration, and presentation of cell surface receptors. Moreover, deregulation of RAB1 expression has been linked to a myriad of human diseases such as cancer, cardiomyopathy and Parkinson’s disease. Further investigating these new physiological and pathological functions of Rab1 should provide new opportunities for better understanding of the disease processes and may lead to more effective therapeutic interventions.