36.Effect of Single-pill Irbesartan/Amlodipine Combination-Based Therapy on Clinic and Home Blood Pressure Profiles in Hypertension with Chronic Kidney Disease
36.Effect of Single-pill Irbesartan/Amlodipine Combination-Based Therapy on Clinic and Home Blood Pressure Profiles in Hypertension with Chronic Kidney Disease
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36.厄贝沙坦/氨氯地平单药联合治疗对慢性肾病高血压患者临床和家庭血压的影响
DOI：
10.1080/10641963.2016.1200063
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发表时间：
2016
影响因子：
12.3
通讯作者：
Umemura S
中科院分区：
文献类型：
--
作者：
Kobayashi R;Tamura K;Wakui H;Ohsawa M;Azushima K;Haku S;Uneda K;Ohki K; Haruhara K;Kinguchi S;Umemura S
我们通过评估自我测量的家庭血压（BP）曲线，检查了20例高血压慢性肾脏病（CKD）患者接受单丸厄贝沙坦/阿托伐他汀联合治疗12周的疗效。单丸厄贝沙坦/厄贝沙坦联合治疗降低了门诊血压和家庭血压（早晨、晚上和夜间血压），改善了访视内门诊血压变异性、每日家庭血压变异性（早晨和晚上）和夜间家庭血压变异性。此外，单丸组合为基础的治疗减少蛋白尿和发挥改善的血管功能参数。这些结果表明，这种单丸组合为基础的治疗可能会发挥有益的影响，对临床和家庭血压的档案，以及对肾脏和血管的损害，高血压伴CKD。
We examined the efficacy of single-pill irbesartan/amlodipine combination-based therapy for 12 weeks in 20 hypertensive chronic kidney disease (CKD) patients, by evaluating self-measured home blood pressure (BP) profile. The single-pill irbesartan/amlodipine combination-based therapy decreased clinic BP and home BP (morning, evening, and nighttime BPs), and improved within-visit clinic BP variability, day-by-day home BP variability (morning and evening), and nighttime home BP variability. Furthermore, the single-pill combination-based therapy reduced albuminuria and exerted improved parameters of vascular function. These results indicate that this single-pill combination-based therapy may exert beneficial effects on clinic and home BP profiles as well as on renal and vascular damages, in hypertension with CKD.