Spinal and peripheral mechanisms of cannabinoid antinociception: behavioral, neurophysiological and neuroanatomical perspectives
Spinal and peripheral mechanisms of cannabinoid antinociception: behavioral, neurophysiological and neuroanatomical perspectives
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DOI：
10.1016/s0009-3084(02)00154-8
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发表时间：
2002-12-31
影响因子：
3.4
通讯作者：
Hohmann, AG
中科院分区：
文献类型：
--
作者：
Hohmann, AG
大量文献表明，大麻素抑制对急性和持续伤害性刺激的行为反应。这篇综述考察了行为、神经生理学和神经解剖学证据，支持大麻素在抑制脊髓和外周水平的伤害性传递中的作用。亚型选择性竞争性拮抗剂和高亲和力激动剂的发展为研究大麻素的抗伤害机制提供了必要的药理学工具。这些研究深入了解了大麻素受体亚型CBI和CB2在急性和持续性(躯体炎症、内脏炎症、神经病理性)疼痛动物模型中所揭示的大麻素抗伤害感受机制中的功能作用。本文综述了受体结合、定量放射自显影、免疫细胞化学和原位杂交的定位研究，以检测大麻素受体在这些水平上的分布，并为了解内源性大麻素在感觉加工中的作用提供了神经解剖学框架。(C)2002爱思唯尔科学爱尔兰有限公司。保留所有权利。
A large body of literature indicates that cannabinoids suppress behavioral responses to acute and persistent noxious stimulation. This review examines behavioral, neurophysiological and neuroanatomical evidence supporting a role for cannabinoids in suppressing nociceptive transmission at spinal and peripheral levels. The development of subtype-selective competitive antagonists and high-affinity agonists provides the pharmacological tools required to study cannabinoid antinociceptive mechanisms. These studies provide insight into the functional roles of cannabinoid receptor subtypes, CBI and CB2, in cannabinoid antinociceptive mechanisms as revealed in animal models of acute and persistent (somatic inflammatory; visceral inflammatory, neuropathic) pain. Localization studies employing receptor binding and quantitative autoradiography, immunocytochemistry and in situ hybridization are reviewed to examine the distribution of cannabinoid receptors at these levels and provide a neuroanatomical framework with which to understand the roles of endogenous cannabinoids in sensory processing. (C) 2002 Elsevier Science Ireland Ltd. All rights reserved.