Transcranial focused ultrasound to the thalamus alters anesthesia time in rats.
Transcranial focused ultrasound to the thalamus alters anesthesia time in rats.
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DOI：
10.1097/wnr.0b013e32834b2957
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发表时间：
2011-10-26
期刊：
影响因子：
1.7
通讯作者：
Park S
中科院分区：
文献类型：
--
作者：
Yoo SS;Kim H;Min BK;Franck E;Park S
聚焦超声（FUS）对局部脑组织的脉冲应用改变了组织兴奋性的状态，从而为非侵入性功能性神经调节提供了手段。我们报告，应用经颅FUS麻醉大鼠丘脑减少时间出现自主运动从腹腔氯胺酮-甲苯噻嗪麻醉。将低强度FUS应用于麻醉动物的丘脑。测量动物显示明显生理/行为变化所需的时间，并与无超声处理的对照期所需的时间进行比较。超声处理显着减少的时间，显示捏反应和自主运动。FUS对麻醉的调节作用提示了对意识障碍（如最低意识状态）的潜在治疗应用。
Pulsed application of focused ultrasound (FUS) to the regional brain tissue alters the state of tissue excitability, and thus provides the means for non-invasive functional neuromodulation. We report that the application of transcranial FUS to the thalamus of anesthetized rats reduced the time to emergence of voluntary movement from intraperitoneal ketamine-xylazine anesthesia. Low intensity FUS was applied to the thalamus of anesthetized animals. The times required for the animals to show distinct physiological/behavioral changes were measured and compared to those times required in a control session without sonication. The sonication significantly reduced the time to show pinch response and voluntary movement. The modulatory effects of FUS on anesthesia suggest potential therapeutic applications for disorders of consciousness such as minimally consciousness states.