Identification in the HLA class I region of a gene expressed late in keratinocyte differentiation.
Identification in the HLA class I region of a gene expressed late in keratinocyte differentiation.
复制标题
鉴定 HLA I 类区域角质形成细胞分化晚期表达的基因。
DOI：
10.1073/pnas.90.20.9470
复制
发表时间：
1993
影响因子：
11.1
通讯作者：
Chaplin,DD
中科院分区：
文献类型：
--
作者：
Zhou,Y;Chaplin,DD
A gene designated S has been identified in the class I region of the human major histocompatibility complex. The S gene is located 160 kb telomeric of HLA-C. It is expressed at high levels as 2.2-kb and 2.6-kb mRNAs in human skin. No homologous transcripts were detected in other tissues including placenta, liver, spleen, thymus, and brain. In situ hybridization showed that S gene expression was restricted to the differentiating keratinocytes in the granular layer of the epidermis. The predicted amino acid sequence of the S protein was remarkable for its high content of serine, glycine, and proline. There were significant similarities with the amino acid sequences of loricrin, keratin 1, and keratin 10, all major components of the granular-cell layer. The selective expression of the S gene in the granular-cell layer in the epidermis suggests a role in the developmental program of differentiating keratinocytes. Furthermore, in light of the recognized association of psoriasis vulgaris, a disorder of keratinocyte proliferation, with alleles of HLA-C, this gene may contribute primarily to the pathogenesis of this common disorder.
