Tolerance and cross-tolerance in chronic alcoholics: reduced membrane binding of ethanol and other drugs.
Tolerance and cross-tolerance in chronic alcoholics: reduced membrane binding of ethanol and other drugs.
复制标题
慢性酗酒者的耐受性和交叉耐受性：乙醇和其他药物的膜结合减少。
DOI：
10.1126/science.6264608
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发表时间：
1981
期刊：
影响因子：
--
通讯作者：
Rubin,E
中科院分区：
文献类型：
--
作者：
Rottenberg,H;Waring,A;Rubin,E
长期饮用乙醇后，大鼠脑突触体和肝脏线粒体中乙醇、麻醉剂和疏水分子的膜结合明显减少。这种膜可以抵抗乙醇和氟烷造成的结构紊乱。慢性酒精成瘾者的耐受性、交叉耐受性和依赖性部分可能是由于膜改变抑制了乙醇和其他药物的结合。
Membrane binding of ethanol, anesthetics, and hydrophobic molecules in brain synaptosomes and liver mitochondria from rats is conspicuously reduced after long-term consumption of ethanol. The membranes are resistant to structural disordering by both ethanol and halothane. Tolerance, cross-tolerance, and dependence in chronic alcoholics may in part result from membrane alterations that inhibit the binding of ethanol and other drugs.