Probiotic bacteria reduced duration and severity but not the incidence of common cold episodes in a double blind, randomized, controlled trial
Probiotic bacteria reduced duration and severity but not the incidence of common cold episodes in a double blind, randomized, controlled trial
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DOI：
10.1016/j.vaccine.2006.05.048
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发表时间：
2006-11-10
期刊：
影响因子：
5.5
通讯作者：
Schrezenmeir, Juergen
中科院分区：
文献类型：
--
作者：
de Vrese, Michael;Winkler, Petra;Schrezenmeir, Juergen
为了研究长期食用益生菌对病毒性呼吸道感染（普通感冒、流感）的影响，在两个冬季/春季期间（3个月和5个月）进行了随机、双盲、对照干预研究。479名健康成年人每天补充维生素和矿物质，有或没有益生菌乳酸杆菌和双歧杆菌。益生菌的摄入对普通感冒感染的发病率没有影响（真实= 158，对照= 153次发作，未观察到流感），但显著缩短了发作持续时间近2天（7.0 +/- 0.5 vs 8.9 +/- 1.0天，p = 0.045），减轻了症状的严重程度，并导致细胞毒性T + T抑制细胞计数和T辅助细胞计数的较大增加。(c)2006爱思唯尔有限公司保留所有权利。
To investigate the effect of long-term consumption of probiotic bacteria on viral respiratory tract infections (common cold, influenza), a randomized, double blind, controlled intervention study was performed during two winter/spring periods (3 and 5 month). Four hundred and seventy-nine healthy adults were supplemented daily with vitamins plus minerals with or without probiotic lactobacilli and bifidobacteria. The intake of the probiotic had no effect on the incidence of common cold infections (verum = 158, control = 153 episodes, influenza was not observed), but significantly shortened duration of episodes by almost 2 days (7.0 +/- 0.5 versus 8.9 +/- 1.0 days, p = 0.045), reduced the severity of symptoms and led to larger increases in cytotoxic T plus T suppressor cell counts and in T helper cell counts. (c) 2006 Elsevier Ltd. All rights reserved.