Multichannel recordings from membranes which contain gap junctions. II. Substates and conductance shifts.
Multichannel recordings from membranes which contain gap junctions. II. Substates and conductance shifts.
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来自包含间隙连接的膜的多通道记录。
DOI：
10.1016/s0006-3495(93)81193-7
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发表时间：
1993
影响因子：
3.4
通讯作者：
Brink,PR
中科院分区：
文献类型：
--
作者：
Ramanan,SV;Brink,PR
在蚯蚓隔膜的100-pS通道中发现了可以持续几秒钟的亚态，这是一种假定的间隙连接通道。这些基态的电导率在不同的制备过程中变化很大，它们几乎存在于整个通道电导率的每一个部分。在多通道记录中看到的另一个现象是“电导移位”：在这里，几个打开的通道通过的电流不同于只有一个通道打开时电流的整数倍。这些位移可以通过1)与通道串联的电阻或2)长寿命的基态来模拟。在特定情况下，这些模型都无法解释变化的幅度或方向。这两种效应可能同时存在。
Substates which can last up to several seconds are found in the 100-pS channel of the earthworm septum, a putative gap junction channel. The conductance of these substates is highly variable from preparation to preparation, and they are found at almost every fraction of the whole channel conductance. Another phenomenon seen in multichannel recordings is the "conductance shift": here the current passed by several open channels differs from an integral multiple of the current when only one channel is open. These shifts can be modelled by 1) a resistance in series with the channel or 2) long-lived substates. Each of these models fails in particular cases to explain either the magnitude or direction of the shifts. It is possible that both effects are simultaneously present.