SEVERE FUNCTIONAL DECLINES, WORK DISABILITY, AND INCREASED MORTALITY IN 75 RHEUMATOID-ARTHRITIS PATIENTS STUDIED OVER 9 YEARS
SEVERE FUNCTIONAL DECLINES, WORK DISABILITY, AND INCREASED MORTALITY IN 75 RHEUMATOID-ARTHRITIS PATIENTS STUDIED OVER 9 YEARS
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DOI：
10.1002/art.1780270805
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发表时间：
1984-01-01
影响因子：
--
通讯作者：
VAUGHN, WK
中科院分区：
文献类型：
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作者：
PINCUS, T;CALLAHAN, LF;VAUGHN, WK
对75例类风湿性关节炎（RA）患者进行了9年的广泛评估，包括功能能力的定量测量。这些患者在病程早期接受了多次关节内注射塞替派和皮质类固醇，但在人口统计学和功能上与其他未接受这种治疗的RA患者相似。在55名存活患者中，在9年期间观察到严重的发病率，包括92%的研究患者的总体功能能力显著降低，93%的握力降低和84%的纽扣试验结果延长。在65岁以下的患者中，85%的患者在疾病发作时一直全职工作。在9年回顾中，死亡率增加，与转诊中心报告的大多数RA患者系列相似;由于关节内使用噻替派而引起关注的肿瘤形成显著增加，未观察到。在功能能力方面，包括对有关活动能力、步行时间和按钮测试的问题的回答，在审查前死亡的患者的基线值显著低于存活患者。在75名患者中，20人死亡，51人在9年的时间内失去了重要的功能能力，通过功能能力的定量测量记录。
Patients (75) with rheumatoid arthritis (RA) were reviewed 9 yr after an extensive evaluation which included quantitative measures of functional capacity. These patients had received multiple intraarticular injections of thiotepa with corticosteroids early in their course, but appear demographically and functionally similar to other RA patients who had not received this therapy. Severe morbidity was seen over the 9 yr period in the 55 surviving patients, including significantly lower overall functional capacity in 92% of patients studied, lower grip strength in 93% and longer button test results in 84%. Work disability occurred in 85% of patients under age 65 who had been working full-time at disease onset. There was increased mortality at the 9-yr review, similar to most reported series of RA patients from referral centers; a significant increase in neoplasia, which was of concern because of the use of intraarticular thiotepa, was not seen. In terms of functional capacity, including responses to questions about ability to perform activities, walking time, and the button test, those patients who had died prior to review had significantly lower baseline values than did those who survived. Of the 75 patients, 20 had died and 51 had lost significant functional capacity over a 9 yr period, documented by quantitative measures of functional capacity.