Intraoperative administration of intravenous flurbiprofen axetil with nalbuphine reduces postoperative pain after orbital decompression: a single-center, prospective randomized controlled trial
Intraoperative administration of intravenous flurbiprofen axetil with nalbuphine reduces postoperative pain after orbital decompression: a single-center, prospective randomized controlled trial
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术中静脉注射氟比洛芬酯联合纳布啡可减轻眼眶减压术后疼痛：一项单中心、前瞻性随机对照试验
DOI：
10.2147/jpr.s187020
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发表时间：
2019
影响因子：
2.7
通讯作者：
Wenjun Guo
中科院分区：
文献类型：
--
作者：
Huijing Ye;Xiufen Lian;Rongxin Chen;Yanling Zhu;Hongbin Chen;Jingxia Huang;Ling Xie;Wenfang Ma;Huasheng Yang;Wenjun Guo
目的观察氟比洛芬酯联合纳布啡用于眼眶减压术后镇痛的效果。方法在中山大学中山眼科中心全麻下行眼眶减压术63例（中国广州）随机分为以下三组之一（1：1：1）：术中氟比洛芬酯100 mg（组1），术中纳布啡0.1 mg/kg（组2），或术中氟比洛芬酯100 mg联合纳布啡0.1 mg/kg（组3）。主要终点是术后24小时内的平均疼痛强度。次要疗效终点为术后0、2、6、10和24小时的疼痛和不适强度以及术后24小时的副作用。结果3组人口学特征相似。第3组术后前24小时的平均和峰值疼痛评分低于第1组（分别为P=0.007和P=0.003）和第2组（分别为P=0.001和P=0.000）。此外，在术后前6小时内，第3组的疼痛评分显著低于第1组（P=0.003、0.002和0.022，分别在0、2和6小时）和第2组在术后前10小时内（0、2、6和10小时时，P分别为0.008、0.000、0.001和0.019）。在观察期间，三组之间的不适评分无显著差异，但在术后2小时，第3组的评分显著低于第2组（P=0.033）。术后不良反应和镇痛需求在三组之间相似。结论氟比洛芬酯联合纳布啡用于眼眶减压术的安全性上级单纯氟比洛芬酯或纳布啡。
Purpose This study aimed to investigate postoperative analgesia achieved with intraoperative administration of intravenous flurbiprofen axetil and nalbuphine in patients undergoing orbital decompression. Methods Sixty-three patients undergoing orbital decompression under general anesthesia at the Zhongshan Ophthalmic Center at Sun Yat-sen University (Guangzhou, China) were randomly allocated into one of the following three groups (1:1:1): intraoperative flurbiprofen axetil 100 mg (Group 1); intraoperative nalbuphine 0.1 mg/kg (Group 2); or intraoperative flurbiprofen axetil 100 mg combined with nalbuphine 0.1 mg/kg (Group 3). The primary end point was mean postoperative pain intensity during the first 24 hours. The secondary efficacy end points were the intensity of pain and discomfort at 0, 2, 6, 10, and 24 hours after surgery and side effects at 24 hours after surgery. Results The demographic characteristics were similar among the three groups. Mean and peak postoperative pain scores during the first 24 hours in Group 3 were lower than those in Group 1 (P=0.007 and P=0.003, respectively) and Group 2 (P=0.001 and P=0.000, respectively). Additionally, the pain scores in Group 3 were significantly lower than those in Group 1 during the first 6 hours after surgery (P=0.003, 0.002, and 0.022 at 0, 2, and 6 hours, respectively) and those in Group 2 during the first 10 hours after surgery (P=0.008, 0.000, 0.001, and 0.019 at 0, 2, 6, and 10 hours, respectively). Discomfort scores were not significantly different among the three groups during the observation period, except at 2 hours after surgery, at which time the scores in Group 3 were significantly lower than those in Group 2 (P=0.033). Postoperative adverse effects and analgesic requirements were similar among the three groups. Conclusion Intraoperative administration of a combination of intravenous flurbiprofen axetil and nalbuphine is superior to single-dose flurbiprofen axetil or nalbuphine in patients undergoing orbital decompression.