Resynchronization of circadian oscillators and the east-west asymmetry of jet-lag
Resynchronization of circadian oscillators and the east-west asymmetry of jet-lag
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DOI：
10.1063/1.4954275
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发表时间：
2016-09-01
期刊：
影响因子：
2.9
通讯作者：
Ott, Edward
中科院分区：
文献类型：
--
作者：
Lu, Zhixin;Klein-Cardena, Kevin;Ott, Edward
已知大脑视交叉上核 (SCN) 中的细胞可以调节哺乳动物的昼夜节律。我们使用强迫 Kuramoto 模型对 SCN 细胞的同步进行建模，该模型由大量具有异质固有频率和外部周期性强迫的耦合相位振荡器（对单个 SCN 细胞进行建模）组成。在这里，周期性强迫模拟了昼夜变化的外部输入，例如日出、日落和闹钟。我们使用 Ott 和 Antonsen 的 ansatz 降低系统的维数，然后研究时钟相位突然变化的影响以模拟跨时区旅行。我们从之前的生物实验中估计模型参数。通过检查模型的相空间动力学，我们研究了导致向东和向西旅行引起的时差严重程度通常存在差异的机制。由 AIP 出版社出版。
Cells in the brain's Suprachiasmatic Nucleus (SCN) are known to regulate circadian rhythms in mammals. We model synchronization of SCN cells using the forced Kuramoto model, which consists of a large population of coupled phase oscillators (modeling individual SCN cells) with heterogeneous intrinsic frequencies and external periodic forcing. Here, the periodic forcing models diurnally varying external inputs such as sunrise, sunset, and alarm clocks. We reduce the dimensionality of the system using the ansatz of Ott and Antonsen and then study the effect of a sudden change of clock phase to simulate cross-time-zone travel. We estimate model parameters from previous biological experiments. By examining the phase space dynamics of the model, we study the mechanism leading to the difference typically experienced in the severity of jet-lag resulting from eastward and westward travel. Published by AIP Publishing.