Morphometric texture analysis of spinal trabecular bone structure assessed using orthogonal radiographic projections
Morphometric texture analysis of spinal trabecular bone structure assessed using orthogonal radiographic projections
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DOI：
10.1118/1.598391
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发表时间：
1998-10-01
期刊：
影响因子：
3.8
通讯作者：
Genant, HK
中科院分区：
文献类型：
--
作者：
Ouyang, XL;Majumdar, S;Genant, HK
骨显微结构和骨密度的测量可以改善骨强度的估计。将人尸体椎骨的立方体标本（N=26，12 mm × 12 mm × 12 mm）沿沿着三个正交解剖方向切割，即，上-下（SI）、内侧-外侧（ML）和前-后（AP）。获得沿着所有三个方向的骨立方体的接触射线照片，然后通过像素大小为50 μ m × 50 μ m的激光扫描仪进行数字化。沿沿着3个正交方向对样本进行压缩测试，并计算每个方向的杨氏模量（YM）。定量计算机断层扫描（QCT）用于测量骨小梁矿物质密度（BMD）。采用全局灰度阈值法和局部阈值法提取骨小梁网络。从提取的骨小梁网络中测量表观骨小梁分数（ABV/TV）、平均截距长度（LTH）、平均截距间隔（LSP）和节点数（N.ND）。还测量了松质骨纹理的分形维数（Fr.D）。配对t检验表明，各质地参数（ABV/TV除外）和YM沿着SI方向的平均值差异显著（p <0.05）。
The measurement of bone microstructure as well as bone mineral density may improve the estimation of bone strength. Cubic specimens (N=26, 12 mmX12 mmX12 mm) of human cadaver vertebrae were cut along three orthogonal anatomic orientations, i.e., superior-inferior (SI), medial-lateral (ML), and anterior-posterior (AP). Contact radiographs of the bone cubes along all three orientations were obtained and then digitized by a laser scanner with pixel size of 50 mu mX50 mu m. The specimens were tested in compression along the 3 orthogonal orientations and the Young's modulus (YM) was calculated for each direction. Quantitative computed tomography (QCT) was used to obtain a measure of trabecular bone mineral density (BMD). Global gray level thresholding and local thresholding algorithms were used to extract the trabecular bone network. Apparent trabecular bone fraction (ABV/TV), mean intercept length (LTH), mean intercept separation (LSP), and number of nodes (N.ND) were measured from the extracted trabecular network. Fractal dimension (Fr.D) of the trabecular bone texture was also measured. Paired t-tests showed that the mean values of each texture parameter (except ABV/TV) and of YM along the SI direction were significantly different (p