Effects of adrenalectomy and corticosterone administration on mouse lung tumor susceptibility and histogenesis.
Effects of adrenalectomy and corticosterone administration on mouse lung tumor susceptibility and histogenesis.
复制标题
肾上腺切除术和皮质酮给药对小鼠肺肿瘤易感性和组织发生的影响。
DOI：
10.1093/jnci/80.5.365
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发表时间：
1988
期刊：
影响因子：
--
通讯作者：
Malkinson,AM
中科院分区：
文献类型：
--
作者：
Droms,KA;Fernandez,CA;Thaete,LG;Malkinson,AM
肾上腺切除术（Ax）对肾上腺素诱导的肺肿瘤的影响在其各自的肿瘤易感性不同的小鼠品系中测定：A/J（敏感），BALB/cByJ（中间）和C57 BL/6 J（B6，抗性）。Ax使A/J（25%）和B6小鼠（400%）的肿瘤数量增加，但在BALB/cByJ小鼠中没有增加。腺泡状或乳头状腺瘤的相对比例没有变化。将含皮质酮的颗粒植入肾上腺切除的B6小鼠中，肿瘤多样性恢复到假手术小鼠的水平，而植入肾上腺切除的A/J小鼠中，肿瘤多样性降低到假手术小鼠的水平以下。因此，皮质酮调节小鼠肺上皮细胞的肿瘤发育。
The effects of adrenalectomy (Ax) on urethan-induced lung tumors were determined in strains of mice that vary in their respective tumor susceptibilities: A/J (sensitive), BALB/cByJ (intermediate), and C57BL/6J (B6, resistant). Ax increased tumor number in both A/J (by 25%) and B6 mice (by 400%), but not in BALB/cByJ mice. The relative proportions of adenomas exhibiting the alveolar or papillary histological growth patterns were unchanged. Implantation of corticosterone-containing pellets into adrenalectomized B6 mice restored tumor multiplicity to that of sham-operated mice and into adrenalectomized A/J mice reduced multiplicity below that of sham-operated mice. Corticosterone, therefore, regulates neo-plastic development of mouse lung epithelial cells.