Relationship of isoniazid resistance to human immunodeficiency virus infection in patients with tuberculosis.
Relationship of isoniazid resistance to human immunodeficiency virus infection in patients with tuberculosis.
复制标题
结核病患者异烟肼耐药与人类免疫缺陷病毒感染的关系。
DOI：
10.1164/ajrccm.153.5.8630625
复制
发表时间：
1996
期刊：
影响因子：
--
通讯作者：
Barnes,PF
中科院分区：
文献类型：
--
作者：
Asch,S;Knowles,L;Rai,A;Jones,BE;Pogoda,J;Barnes,PF
为了研究结核病患者对异烟肼耐药与HIV感染之间的关系，我们评估了洛杉矶县结核病登记处1,506例患者的数据，这些患者有药物敏感性结果。在235名HIV感染者中，异烟肼耐药的发生率低于1,271名HIV血清阴性或未进行HIV检测的患者，未校正的比值比为0.3。在调整了其他影响耐药的因素（种族、出生国、既往结核病诊断和空洞）后，异烟肼耐药的频率仍低于未感染HIV的患者，比值比为0.4（95%置信区间，0.2至0.8; p = 0.02）。我们的结论是，在洛杉矶，没有持续的耐药结核病爆发的设置，异烟肼耐药结核病是不是更常见的艾滋病毒感染患者。
To investigate the relationship between isoniazid resistance and HIV infection in patients with tuberculosis, we evaluated data in the Los Angeles County tuberculosis registry on 1,506 patients for whom drug susceptibility results were available. Among 235 HIV-infected patients, isoniazid resistance was less common than in 1,271 patients who were HIV-seronegative or who had not been tested for HIV, with an unadjusted odds ratio of 0.3. After adjustment for other factors that affect drug resistance (ethnicity, country of birth, prior diagnosis of tuberculosis, and cavitation), the frequency if isoniazid resistance remained lower than that in patients without HIV infection, with an odds ratio of 0.4 (95% confidence interval, 0.2 to 0.8; p = 0.02). We conclude that in Los Angeles, a setting where there is no ongoing outbreak of drug-resistant tuberculosis, isoniazid-resistant tuberculosis is not more common in HIV-infected patients.