Mammalian Sterile20-like Kinases: Signalings and Roles in Central Nervous System.
Mammalian Sterile20-like Kinases: Signalings and Roles in Central Nervous System.
复制标题
哺乳动物不育20样激酶：中枢神经系统中的信号传导和作用
DOI：
10.14336/ad.2017.0702
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发表时间：
2018-06
影响因子：
7.4
通讯作者：
Zhang J
中科院分区：
文献类型：
--
作者：
Chen S;Fang Y;Xu S;Reis C;Zhang J
哺乳动物Sterile 20-like（MST）激酶位于丝裂原活化蛋白激酶通路的上游，在细胞增殖、分化、更新、极化和迁移中发挥重要作用。哺乳动物信号转导通路中通常存在五种MST激酶，包括MST 1、MST 2、MST 3、MST 4和YSK 1。中枢神经系统（CNS）是一个复杂的实体，负责信息的接收，整合和反应。最近，越来越多的证据表明，MST激酶在涉及CNS的不同系统的疾病发展中是至关重要的。本文就MST激酶的信号转导途径及其相互作用蛋白进行综述。每一个MST激酶的潜在的生物学功能和常见的MST相关疾病的神经系统进行了审查。进一步研究MST激酶及其与中枢神经系统疾病的相互作用将为医学界提供人类疾病的新治疗靶点。
Mammalian Sterile20-like (MST) kinases are located upstream in the mitogen-activated protein kinase pathway, and play an important role in cell proliferation, differentiation, renewal, polarization and migration. Generally, five MST kinases exist in mammalian signal transduction pathways, including MST1, MST2, MST3, MST4 and YSK1. The central nervous system (CNS) is a sophisticated entity that takes charge of information reception, integration and response. Recently, accumulating evidence proposes that MST kinases are critical in the development of disease in different systems involving the CNS. In this review, we summarized the signal transduction pathways and interacting proteins of MST kinases. The potential biological function of each MST kinase and the commonly reported MST-related diseases in the neural system are also reviewed. Further investigation of MST kinases and their interaction with CNS diseases would provide the medical community with new therapeutic targets for human diseases.