TRIENNIAL LACTATION SYMPOSIUM/BOLFA: Plasticity of mammary development in the prepubertal bovine mammary gland
TRIENNIAL LACTATION SYMPOSIUM/BOLFA: Plasticity of mammary development in the prepubertal bovine mammary gland
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DOI：
10.2527/jas2017.1792
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发表时间：
2017-12-01
影响因子：
3.3
通讯作者：
Akers, R. M.
中科院分区：
文献类型：
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作者：
Akers, R. M.
尽管青春期周围的乳腺发育只占妊娠末期和哺乳期乳腺实质总质量的一小部分，但越来越多的证据表明，早期形成的组织基础可以影响未来乳腺的发育和功能。对雌激素和孕激素受体表达的研究似乎证实了这些类固醇在青春期前乳腺发育中的相关性，但与其他生长因子、激素和局部组织因子的联系尚不明确。增强断奶前喂养的牛似乎增强了乳腺组织对乳腺刺激的反应能力。这表明，改善早期营养可能允许干细胞或祖细胞群的产生，以更好地支持妊娠期间巨大的导管生长和小叶-肺泡发育。越来越多的证据表明，免疫细胞参与了乳房发育，这表明免疫系统和乳房发育之间存在着意想不到的、鲜为人知的联系。这在反刍动物中几乎是未知的。开发新的工具来鉴定、分离和表征发育中的牛乳腺细胞群，为鉴定和改变乳腺干细胞或选定的祖细胞群以调节乳腺发育和乳腺功能提供了可能。
Although peripubertal mammary development represents only a small fraction of the total mass of mammary parenchyma present in the udder at the end of gestation and into lactation, there is increasing evidence that the tissue foundations created in early life can affect future mammary development and function. Studies on expression of estrogen and progesterone receptors seem to confirm the relevance of these steroids in prepubertal mammary development, but connections with other growth factors, hormones, and local tissue factors remain elusive. Enhanced preweaning feeding in the bovine appears to enhance the capacity of mammary tissue to response to mammogenic stimulation. This suggests the possibility that improved early nutrition might allow for creation of stem or progenitor cell populations to better support the massive ductal growth and lobulo-alveolar development during gestation. Increasing evidence that immune cells are involved in mammary development suggests there are unexpected and poorly understood connections between the immune system and mammary development. This is nearly unexplored in ruminants. Development of new tools to identify, isolate, and characterize cell populations within the developing bovine mammary gland offer the possibility of identifying and perhaps altering populations of mammary stem cells or selected progenitor cells to modulate mammary development and, possibly, mammary function.