Occurrence of neutrophil extracellular DNA traps (NETs) in pre-eciampsia - A link with elevated levels of cell-free DNA?
Occurrence of neutrophil extracellular DNA traps (NETs) in pre-eciampsia - A link with elevated levels of cell-free DNA?
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DOI：
10.1196/annals.1368.015
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发表时间：
2006-01-01
期刊：
影响因子：
--
通讯作者：
Hahn, Sinuhe
中科院分区：
文献类型：
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作者：
Gupta, Anurag;Hasler, Paul;Hahn, Sinuhe
明显的先兆子痫与外周中性粒细胞的激活以及母体游离DNA的升高有关。出于这个原因，我们对最近的报告非常感兴趣，该报告表明激活的循环中性粒细胞分泌核 DNA 以生成细胞外 DNA 晶格，称为 NET（中性粒细胞胞外陷阱）。我们的初步数据表明，在先兆子痫中释放大量的胎盘合体滋养层微粒可以在分离的中性粒细胞中诱导 NET。此外，我们发现了先兆子痫胎盘绒毛间隙中直接存在 NET 增加的证据。因此，这些新发现的实体可能与这种疾病的潜在病因有关。
Manifest pre-eclampsia is associated with activation of peripheral neutrophils as well as elevations in maternal cell-free DNA. For this reason, we were very intrigued by recent reports indicating that activated circulatory neutrophils secrete nuclear DNA to generate extracellular DNA lattices, termed NETs (neutrophil extracellular traps). Our preliminary data indicate that placental syncytiotrophoblast microparticles, which are released in elevated amounts in pre-eclampsia, can induce NETs in isolated neutrophils. Furthermore, we found evidence for the increased presence of NETs directly in the intervillous space of preeclamptic placentae. Therefore, these newly discovered entities may be implicated in the underlying etiology of this disorder.