Cancer micrometastases
Cancer micrometastases
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DOI：
10.1038/nrclinonc.2009.44
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发表时间：
2009-06-01
影响因子：
78.8
通讯作者：
Riethdorf, Sabine
中科院分区：
文献类型：
--
作者：
Pantel, Klaus;Alix-Panabieres, Catherine;Riethdorf, Sabine
目前的成像技术通常无法检测到肿瘤细胞的早期扩散。在没有明显转移迹象的癌症患者中，已经开发了检测外周血中的循环肿瘤细胞（CTC）和骨髓中的播散肿瘤细胞（DTC）的敏感方法。这些技术可以分为细胞计数和/或免疫学和分子方法。有趣的是，骨髓似乎是来源于各种上皮肿瘤的细胞的常见归巢组织，来自欧洲和美国组的1a级数据证实了DTC在乳腺癌患者骨髓中的预后影响。然而，对于实体瘤患者，连续的外周血分析比骨髓分析更方便，并且许多研究小组目前正在评估CTC用于评估预后和监测系统治疗的临床应用。DTC和CTC的分子表征为理解癌症休眠开辟了新的途径，并可能有助于识别转移性干细胞，对未来的治疗具有重要意义。本文就近年来肿瘤患者血液传播性肿瘤微转移的最新研究成果的临床意义进行综述。
Early spread of tumor cells is usually undetected by current imaging technologies. in patients with cancer and no signs of overt metastases sensitive methods have been developed to detect circulating tumor cells (CTCs) in the peripheral blood and disseminated tumor cells (DTCs) in the bone marrow. These technologies can be classified into cytometric and/or immunological and molecular approaches. interestingly, the bone marrow seems to be a common homing tissue for cells derived from various epithelial tumors, and level 1a data from european and US groups have confirmed the prognostic impact of DTCs in the bone marrow of patients with breast cancer. sequential peripheral blood analyses, however, are more convenient than bone marrow analyses for patients with solid tumors, and many research groups are currently assessing the clinical use of CTCs for assessment of prognosis and monitoring of systemic therapy. Molecular characterization of DTCs and CTCs opens a new avenue for understanding cancer dormancy, and might contribute to the identification of metastatic stem cells with important implications for future therapies. This review focuses on the clinical relevance of the latest research results on blood-borne cancer micrometastases in patients with cancer.