The translational research working group developmental pathway for image-based assessment modalities
The translational research working group developmental pathway for image-based assessment modalities
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DOI：
10.1158/1078-0432.ccr-08-1264
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发表时间：
2008-09-15
影响因子：
11.5
通讯作者：
Matrisian, Lynn M.
中科院分区：
文献类型：
--
作者：
Dorfman, Gary S.;Sullivan, Daniel C.;Matrisian, Lynn M.
基于图像的评估模式（IM）途径是指六个转化研究工作组（TRWG）途径之一，这些途径共同描述了早期转化癌症研究的核心领域。该途径侧重于基于能量和活生物体相互作用的方法，以非侵入性方式分析组织，从而揭示与癌症和癌前病变的检测，诊断或预后相关的特性;或癌症对治疗的反应。实例包括但不限于磁共振成像和正电子发射断层扫描，以及设计用于探测肿瘤的特定分子成分的当代造影剂。IM途径作为有效开发、优化、测试和验证基于图像的模态所需步骤的概述。IM途径和遇到的问题，代表通过途径有效和高效的进展的障碍的显着特点进行了讨论。IM途径还形成了一个框架，以确定解决当前障碍的机会，并有望随着该领域的发展而适应和发展。
The Image-based assessment modality (IM) pathway refers to one of six Translational Research Working Group (TRWG) pathways that, together, describe the core domains of early translational cancer research. This pathway focuses on approaches that are based on the interaction of energy and living organisms to analyze tissue noninvasively so as to reveal properties relevant to the detection, diagnosis, or prognosis of cancer and precancer; or the response of the cancer to therapy. Examples include, but are not limited to, magnetic resonance imaging and positron emission tomography, as well as contemporary contrast agents designed to probe specific molecular constituents of tumors. The IM pathway is presented as a general outline of the steps required for the effective development, optimization, testing, and validation of image-based modalities. The distinctive features of the IM pathway and issues encountered that represent obstacles to effective and efficient progress through the pathway are discussed. The IM pathway also forms a framework to identify opportunities to address current barriers and is expected to adapt and evolve as the field advances.