Insights on biology and evolution from microbial genome sequencing
Insights on biology and evolution from microbial genome sequencing
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DOI：
10.1101/gr.3724205
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发表时间：
2005-12-01
期刊：
影响因子：
7
通讯作者：
Fraser-Liggett, CM
中科院分区：
文献类型：
--
作者：
Fraser-Liggett, CM
没有一个研究领域比微生物学领域更多地接受和应用基因组技术。对近300种微生物的比较分析表明，微生物基因组是由多种力量塑造的动态实体。微生物基因组学为广泛的应用提供了基础，从了解基本的生物学过程，宿主-病原体相互作用和蛋白质-蛋白质相互作用，到发现可用于基因分型或法医分析的DNA变异，新型抗微生物化合物和疫苗的设计，以及工业应用的微生物工程。最近，宏基因组学方法允许LIS开始首次探测复杂的微生物群落，并且它们在帮助解开微生物物种之间的关系方面具有很大的希望。
No Field of research has embraced and applied genomic technology more than the field of microbiology. Comparative analysis of nearly 300 microbial species has demonstrated that the microbial genome is a dynamic entity shaped by multiple forces. Microbial genomics has provided a foundation for a broad range of applications, from understanding basic biological processes, host-pathogen interactions, and protein-protein interactions, to discovering DNA variations that can be used in genotyping or forensic analyses, the design of novel antimicrobial compounds and vaccines, and the engineering of microbes for industrial applications. Most recently, metagenomics approaches are allowing LIS to begin to probe complex microbial communities for the first time, and they hold great promise in helping to unravel the relationships between microbial species.