Serum triglycerides as a risk factor for cardiovascular diseases in the Asia-Pacific region
Serum triglycerides as a risk factor for cardiovascular diseases in the Asia-Pacific region
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DOI：
10.1161/01.cir.0000145615.33955.83
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发表时间：
2004-10-26
期刊：
影响因子：
37.8
通讯作者：
Woodward, M
中科院分区：
文献类型：
--
作者：
Patel, A;Barzi, F;Woodward, M
背景-血清甘油三酯水平作为心血管疾病的危险因素的重要性是不确定的。方法和结果-我们进行了一个单独的参与者数据荟萃分析的前瞻性研究在亚太地区进行。将考克斯模型应用于26项研究的合并数据，以通过甘油三酯值的五分之一估计主要心血管疾病的总体和地区、性别和年龄特异性风险比。在对96224人进行的796671人-年的随访中，分别记录了670例和667例因冠心病（CHD）和中风而死亡的病例。在调整了主要的心血管危险因素后，甘油三酯水平最高的五分之一组的参与者有70%的心血管危险因素。（95% CI，47至96）CHD死亡风险增加，80%（95% CI，49 - 119）致死性或非致死性CHD风险较高，（95% CI，29%-76%）与最低五分之一的人相比，致命性或非致命性卒中的风险增加。甘油三酯和冠心病死亡之间的关联是相似的亚组定义的种族，年龄和sex. Conclusions，血清甘油三酯是一个重要的和独立的预测冠心病和中风的风险在亚太地区。这些结果可能对心血管风险预测和降脂治疗的使用具有临床意义。
Background-The importance of serum triglyceride levels as a risk factor for cardiovascular diseases is uncertain.Methods and Results-We performed an individual participant data meta-analysis of prospective studies conducted in the Asia-Pacific region. Cox models were applied to the combined data from 26 studies to estimate the overall and region-, sex-, and age-specific hazard ratios for major cardiovascular diseases by fifths of triglyceride values. During 796 671 person-years of follow-up among 96 224 individuals, 670 and 667 deaths as a result of coronary heart disease (CHD) and stroke, respectively, were recorded. After adjustment for major cardiovascular risk factors, participants grouped in the highest fifth of triglyceride levels had a 70% (95% CI, 47 to 96) greater risk of CHD death, an 80% (95% CI, 49 to 119) higher risk of fatal or nonfatal CHD, and a 50% (95% CI, 29% to 76%) increased risk of fatal or nonfatal stroke compared with those belonging to the lowest fifth. The association between triglycerides and CHD death was similar across subgroups defined by ethnicity, age, and sex.Conclusions-Serum triglycerides are an important and independent predictor of CHD and stroke risk in the Asia-Pacific region. These results may have clinical implications for cardiovascular risk prediction and the use of lipid-lowering therapy.