AIDS-associated malignancies: research perspectives
AIDS-associated malignancies: research perspectives
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DOI：
10.1016/s0304-419x(98)00033-x
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发表时间：
1999-01-29
影响因子：
11.2
通讯作者：
Feigal, EG
中科院分区：
文献类型：
--
作者：
Feigal, EG
1981年，男同性恋者出现了一种通常罕见的恶性肿瘤——卡波西氏肉瘤，这是一种由逆转录病毒——人类免疫缺陷病毒（HIV）引起的流行病的最早征兆之一，这种病毒会导致获得性免疫缺陷综合症（艾滋病）。淋巴和其他恶性肿瘤也有所增加，最显著的是非霍奇金淋巴瘤和原发性中枢神经系统淋巴瘤。分子生物学、免疫学、病毒学和抗病毒治疗的进展相结合，创造了独特的研究机会。一个发展中的主题是病毒合并感染和恶性肿瘤的作用。人类疱疹病毒8 （HHV8）、爱泼斯坦-巴尔病毒（EBV）和乳头瘤病毒都可能在hiv相关恶性肿瘤的发展中起因果作用。新的抗逆转录病毒疗法能够大大逆转或延缓艾滋病毒感染的深刻免疫抑制。恶性肿瘤流行病学的变化以及对这些新疗法的作用机制的了解，为了解这些恶性肿瘤的发病机制提供了研究机会。发现基于t细胞的免疫缺陷的后果和与特定病毒病原体的相互作用的机会将可能导致艾滋病毒治疗和其他恶性肿瘤的新策略的进展。(C) 1998 Elsevier Science B.V.版权所有
The appearance in 1981 of a usually rare malignancy, Kaposi's sarcoma, in homosexual men [1] was one of the first harbingers of an epidemic caused by a retrovirus, human immunodeficiency virus (HIV), which causes the acquired immunodeficiency syndrome (AIDS). Lymphoid and other malignancies were also increased, most strikingly non-Hodgkin's lymphoma and primary central nervous system (CNS) lymphoma. Advances in molecular biology, immunology, virology, and anti-viral therapy have combined to create unique research opportunities. One developing theme is the role of viral coinfection and malignancy. Human herpes virus 8 (HHV8), Epstein-Barr virus (EBV) and papilloma virus each may have a causal role in the development of HIV-associated malignancy. New antiretroviral therapies are able to substantially reverse or delay the profound immunosuppression of HIV infection. The changes in the epidemiology of malignancies, and understanding the mechanism of action of these new therapeutics provide research opportunities to understand the pathogenesis of these malignancies. The opportunities to discover the consequences of T-cell based immunodeficiency and the interactions with specific viral pathogens will likely lead to progress in HIV treatment and new strategies for other malignancies. (C) 1998 Elsevier Science B.V. All rights reserved.