Decreased survival in patients with carcinoma of axillary tail versus upper outer quadrant breast cancers: a SEER population-based study.
Decreased survival in patients with carcinoma of axillary tail versus upper outer quadrant breast cancers: a SEER population-based study.
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与上外象限乳腺癌患者相比，腋尾癌患者的生存率降低：一项基于 SEER 人群的研究。
DOI：
10.2147/cmar.s165291
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发表时间：
2018
影响因子：
3.3
通讯作者：
Shao ZM
中科院分区：
文献类型：
--
作者：
Gou ZC;Liu XY;Xiao Y;Zhao S;Jiang YZ;Shao ZM
斯宾塞腋下尾癌是一种研究较少的乳腺癌类型。猫的临床病理特征和预后特征尚不清楚。使用监测、流行病学和最终结果数据库，我们确定了149,026名被诊断为上外象限乳腺癌(n=146,343)或猫(n=2,683)的患者。中位随访时间为88个月。主要和次要结果是乳腺癌特异性存活率(BCS)和总存活率。采用竞争风险分析、LOG-RANK检验、Cox比例风险回归模型和倾向得分匹配法比较UOBC和CATS的生存结果。用多因素Logistic回归分析CAT与淋巴结转移的关系。猫恶性程度高，激素受体阴性率高，淋巴结转移阳性率高。猫的10年BCS率(85.1%)明显低于UOBC(87.3%，P=0.001)。多因素COX分析显示，猫的风险比(HR)高于UOBC(BCS：HR=1.2，P=0.001；总存活率：HR=1.11，P=0.019)。在1：1匹配的队列中也观察到了BCSs的差异(BCSSP=0.019)。亚组分析显示，在转移性LN亚组和激素受体阴性亚组中，猫的预后较差。多因素Logistic回归分析表明，CAT是LN转移的独立影响因素。CAT具有明显的临床病理特征，更可能与LN转移有关。与UOBC相比，CATS对BCS有不利影响。
Carcinoma of the axillary tail of Spence (CATS) is a poorly studied type of breast cancer. The clinicopathological characteristics and prognostic features of CATS are unclear. Using the Surveillance, Epidemiology, and End Results database, we identified 149,026 patients diagnosed with upper outer quadrant breast cancer (UOBC) (n=146,343) or CATS (n=2,683). The median follow-up was 88 months. The primary and secondary outcomes were breast cancer-specific survival (BCSS) and overall survival. The survival outcomes of UOBC and CATS were compared using competing risks analysis, log-rank test, Cox proportional hazards regression model, and propensity score matching method. Multivariate logistic regression was utilized to present the relationship between CATS and lymph node (LN) metastasis. CATS presented a higher grade, higher negative hormone receptor rate, and more positive nodal metastasis. The 10-year BCSS rate was worse for CATS than for UOBC (85.1% vs 87.3%, P=0.001). The multivariate Cox analysis showed a higher hazard ratio (HR) for CATS over UOBC (BCSS: HR =1.20, P=0.001; overall survival: HR =1.11, P=0.019). The difference in the BCSS was also observed in a 1:1 matched cohort (BCSS P=0.019). A subgroup analysis revealed the inferior outcomes of CATS in the metastatic LN subgroup and the hormone receptor-negative subgroup. The multivariate logistic regression indicated that CATS is an independent contributing factor to LN metastasis. CATS had distinct clinicopathological characteristics and was more likely associated with LN metastasis. Compared to UOBC, CATS had adverse impacts on BCSS.
影响因子：
3.2
作者：
Okubo M;Tada K;Niwa T;Nishioka K;Tsuji E;Ogawa T;Seto Y
通讯作者：
Seto Y