New synthesis of a useful C3 chiral building block by a heterogeneous method: enantioselective hydrogenation of pyruvaldehyde dimethyl acetal over cinchona modified Pt/Al2O3 catalysts
New synthesis of a useful C3 chiral building block by a heterogeneous method: enantioselective hydrogenation of pyruvaldehyde dimethyl acetal over cinchona modified Pt/Al2O3 catalysts
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DOI：
10.1039/a904694a
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发表时间：
1999
影响因子：
4.9
通讯作者：
B. Török;K. Balázsik;M. Bartók;K. Felföldi
中科院分区：
文献类型：
--
作者：
B. Török;K. Balázsik;M. Bartók;K. Felföldi
本文描述了异相金银花修饰Pt催化剂体系在C3手性合成中的首次令人满意的应用，即丙酮醛二甲基缩醛的高对映选择性（高达96.5% ee）加氢成乙醛二甲基缩醛。
The first satisfactory application of the heterogeneous cinchona-modified Pt catalyst system for the synthesis of a C3 chiral building, namely, the highly enantioselective (up to 96.5% ee) hydrogenation of pyruvaldehyde dimethyl acetal to lactaldehyde dimethyl acetal is described.