Social Regulation of Human Gene Expression: Mechanisms and Implications for Public Health
Social Regulation of Human Gene Expression: Mechanisms and Implications for Public Health
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DOI：
10.2105/ajph.2012.301183
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发表时间：
2013-10-01
影响因子：
12.7
通讯作者：
Cole, Steven W.
中科院分区：
文献类型：
--
作者：
Cole, Steven W.
最近的分析发现，人类基因的表达在不同的社会环境中发生了广泛的变化。新兴的社会基因组学领域已经开始识别对社会调节敏感的基因类型、调节这些影响的生物信号通路，以及改变其个体影响的遗传多态。人类基因组似乎进化出了特定的“社会程序”，以使分子生理学适应祖先与不断变化的社会条件相关的威胁和机会的不断变化的模式。在免疫系统的背景下，这种规划现在助长了许多主导公共卫生的疾病。将个体基因组嵌入到一个更广泛的元基因组网络中，为整合人类健康的分子、生理和社会观点提供了一个框架。
Recent analyses have discovered broad alterations in the expression of human genes across different social environments. The emerging field of social genomics has begun to identify the types of genes sensitive to social regulation, the biological signaling pathways mediating these effects, and the genetic polymorphisms that modify their individual impact. The human genome appears to have evolved specific "social programs" to adapt molecular physiology to the changing patterns of threat and opportunity ancestrally associated with changing social conditions. In the context of the immune system, this programming now fosters many of the diseases that dominate public health. The embedding of individual genomes within a broader metagenomic network provides a framework for integrating molecular, physiologic, and social perspectives on human health.