Monthly Observation of the Number of Patients with Kawasaki Disease and its Incidence Rates in Japan: Chronological and Geographical Observation from Nationwide Surveys
Monthly Observation of the Number of Patients with Kawasaki Disease and its Incidence Rates in Japan: Chronological and Geographical Observation from Nationwide Surveys
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DOI：
10.2188/jea.je2008030
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发表时间：
2008-11-01
影响因子：
4.7
通讯作者：
Yanagawa, Hiroshi
中科院分区：
文献类型：
--
作者：
Nakamura, Yosikazu;Yashiro, Mayumi;Yanagawa, Hiroshi
背景：虽然日本川崎病的流行病学特征已经被观察到，但近年来，还没有使用小于全国的观测单位对川崎病患者数量和发病率进行时间和地理观察。方法：我们使用了日本最近5次(第15至19日)全国范围内的川崎病调查，覆盖了10年的患者，即1997-2006年。计算各地市每月就诊人数，并根据各地市目标机构的应答率进行校正。按地区观察患者数量的时间变化。从2001年到2006年的6年间，每两个月观察一次发病率的地理变化。结果：从总体上看，每月发病人数呈逐渐上升趋势。就每年而言，这一数字在1月最高，10月最低；夏季也相对较高。在月度观测方面，各区之间存在一些差异。各县两月一次的发病观察揭示了不同地理区域流行特征的差异。结论：近10年来日本川崎病发病的时间和地理变化提示，一种或多种传染病病原体参与了该病的发生。
Background: Although the epidemiologic features of Kawasaki disease for Japan have been observed, recently, chronological and geographical observations of the number of patients and incidence rate of the disease have not been conducted using observation units smaller than the whole country.Methods: We used the recent 5 nationwide surveys (the 15th to 19th) of Kawasaki disease in Japan, which covered patients for 10 years, i.e., between 1997 and 2006. The monthly number of patients by prefecture was calculated, and the number was corrected by the response rate of the target institutes of the prefecture. Chronological changes in the number of patients were observed by district. Geographical changes in the incidence rates were observed bimonthly by prefecture for the recent 6 years, from 2001 through 2006.Results: On the whole, the monthly number of patients increased gradually. For each year, the number was the highest in January and the lowest in October; it was relatively high during summer as well. Some differences existed among the districts with regard to the monthly observations. Bimonthly observations of the incidence rate by prefecture revealed the differences in the characteristics of the epidemics in different geographic areas.Conclusion: The chronological and geographical changes in the occurrence of Kawasaki disease in Japan for the recent 10 years suggested the involvement of one or more infectious agents in the occurrence of the disease.