STAT3 induces muscle stem cell differentiation by interaction with myoD.
STAT3 induces muscle stem cell differentiation by interaction with myoD.
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DOI：
10.1016/j.cyto.2008.12.015
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发表时间：
2009-04
期刊：
影响因子：
3.8
通讯作者：
Yanping Yang;Ying Xu;Wei Li;Guan-jun Wang;Yanqiu Song;Guozi Yang;Xue Han;Z. Du;Luguo Sun;Kewei Ma
中科院分区：
文献类型：
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作者：
Yanping Yang;Ying Xu;Wei Li;Guan-jun Wang;Yanqiu Song;Guozi Yang;Xue Han;Z. Du;Luguo Sun;Kewei Ma
信号转导和转录激活因子（STAT）家族蛋白是多种细胞因子和激素的重要生物学效应。已知STAT 3蛋白在许多类型细胞的生长、分化和存活的调节中发挥核心作用。然而，STAT 3在肌发生中的功能仍然在很大程度上未知。我们现在提供的直接证据表明，STAT 3可以诱导肌细胞分化，这种作用可能是通过与肌细胞分化过程中的关键转录因子MyoD相互作用介导的。白血病抑制因子（leukemia inhibitory factor，LIF）可能是激活JAK 2/STAT 3通路促进肌细胞分化的上游因子。总之，这些结果为进一步了解肌肉再生机制提供了分子基础。
Signal transducers and activators of transcription (STAT) family proteins transduce pivotal biological effects of various cytokines and hormones. STAT3 proteins are known to play a central role in the regulation of growth, differentiation, and survival of many types of cells. However, the function of STAT3 in myogenesis still remains largely unknown. We now provided direct evidence that STAT3 could induce myogenic differentiation and this effect might be mediated by interaction with MyoD—the essential transcription factor during myogenic differentiation. Furthermore, leukemia inhibitory factor (LIF) might be the upstream factor which activated JAK2/STAT3 pathway to stimulate muscle cell differentiation. Taken together, these results provide a molecular basis for further understanding of the muscle regeneration mechanism.